Journal of Surgical Research
Volume 159, Issue 2 , Pages e37-e43 , April 2010

Significance of Portal Venous VEGF During Liver Regeneration After Hepatectomy

  • Chiduru Yamamoto, M.Sc.

      Affiliations

    • Department of Hepatobiliary and Pancreatic Surgery, Mie University Graduate School of Medicine, Tsu, Japan
  • ,
  • Shintaro Yagi, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary, Pancreas, and Transplant Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Hepatobiliary, Pancreas, and Transplant Surgery, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto city, Kyoto prefecture, Japan 606-8507.
  • ,
  • Tomohide Hori, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary, Pancreas, and Transplant Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • ,
  • Taku Iida, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary, Pancreas, and Transplant Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • ,
  • Kentaro Taniguchi, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary and Pancreatic Surgery, Mie University Graduate School of Medicine, Tsu, Japan
  • ,
  • Shuji Isaji, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary and Pancreatic Surgery, Mie University Graduate School of Medicine, Tsu, Japan
  • ,
  • Shinji Uemoto, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary, Pancreas, and Transplant Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Received 4 September 2008

References 

  1. Nakamura T, Nishizawa T, Hagiya M, et al. Molecular cloning and expression of human hepatocyte growth factor. Nature. 1989;342:440
  2. Kan M, Huang JS, Mansson PE, et al. Heparin-binding growth factor type 1 (acidic fibroblast growth factor): A potential biphasic autocrine and paracrine regulator of hepatocyte regeneration. Proc Natl Acad Sci U S A. 1989;86:7432
  3. McGowan JA, Strain AJ, Bucher NL. DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of epidermal growth factor, insulin, glucagon, and cyclic-AMP. J Cell Physiol. 1981;108:353
  4. Miyazawa K, Shimomura T, Kitamura A, et al. Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. J Biol Chem. 1993;268:10024
  5. Mochida S, Ishikawa K, Inao M, et al. Increased expressions of vascular endothelial growth factor and its receptors, flt-1 and KDR/flk-1, in regenerating rat liver. Biochem Biophys Res Commun. 1996;226:176
  6. Slapak M, Wexler M, Mizumoto R, et al. The role of arterial portal and systemic venous blood on regeneration of the canine liver. Br J Surg. 1970;57:392
  7. Wexler M, Slapak M, Mizumoto R, et al. Regeneration and maintenance of integrity of canine liver. The role of arterial, portal, and systemic venous blood. Arch Surg. 1970;101:267
  8. Starzl TE, Porter KA, Kashiwagi N. Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration. Surg Gynecol Obstet. 1975;141:843
  9. Yagi S, Iida T, Taniguchi K, et al. Impact of portal venous pressure on regeneration and graft damage after living-donor liver transplantation. Liver Transpl. 2005;11:68
  10. Higgins GM, Anderson RM. Experimental pathology of the liver: restoration of the liver the white rat following partial surgical removal. Arch Pathol. 1931;12:186
  11. Bucher NL. Regeneration of mammalian liver. Int Rev Cytol. 1963;15:245
  12. Koniaris LG, Zimmers-Koniaris T, Hsiao EC, et al. Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration. J Immunol. 2001;167:399
  13. Assy N, Spira G, Paizi M, et al. Effect of vascular endothelial growth factor on hepatic regenerative activity following partial hepatectomy in rats. J Hepatol. 1999;30:911
  14. Taniguchi E, Sakisaka S, Matsuo K, et al. Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats. J Histochem Cytochem. 2001;49:121
  15. Shimizu H, Miyazaki M, Wakabayashi Y, et al. Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats. J Hepatol. 2001;34:683
  16. Maeno H, Ono T, Dhar DK, et al. Expression of hypoxia inducible factor-1alpha during liver regeneration induced by partial hepatectomy in rats. Liver Int. 2005;25:1002
  17. Bockhorn M, Schollmann S, Opitz B, et al. Vascular endothelial growth factor does not improve liver regeneration and survival after 90% subtotal liver resection. Hepatol Res. 2007;37:353
  18. Iyer NV, Kotch LE, Agani F, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998;12:149
  19. Gopfert T, Gess B, Eckardt KU, et al. Hypoxia signalling in the control of erythropoietin gene expression in rat hepatocytes. J Cell Physiol. 1996;168:354
  20. LeCouter J, Moritz DR, Li B, et al. Angiogenesis-independent endothelial protection of liver: Role of VEGFR-1. Science. 2003;299:890
  21. Matsumoto K, Tajima H, Okazaki H, et al. Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-β 1 and glucocorticoids. J Biol Chem. 1992;267:24917
  22. Kaido T, Oe H, Yoshikawa A, et al. Expressions of molecules associated with hepatocyte growth factor activation after hepatectomy in liver cirrhosis. Hepatogastroenterology. 2004;51:547
  23. Shimomura T, Miyazawa K, Komiyama Y, et al. Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator. Eur J Biochem. 1995;229:257
  24. Naldini L, Tamagnone L, Vigna E, et al. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. Embo J. 1992;11:4825
  25. Mars WM, Zarnegar R, Michalopoulos GK. Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Am J Pathol. 1993;143:949
  26. Miyazawa K, Shimomura T, Kitamura N. Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. J Biol Chem. 1996;271:3615

PII: S0022-4804(08)00692-6

doi: 10.1016/j.jss.2008.11.007

Journal of Surgical Research
Volume 159, Issue 2 , Pages e37-e43 , April 2010