Journal of Surgical Research
Volume 157, Issue 1 , Pages 71-80 , November 2009

Effects of Bone Marrow and Hepatocyte Transplantation on Liver Injury

  • Biao Zhang, M.D.

      Affiliations

    • Department of Surgery, Asahikawa Medical College, Japan
    • Present address: Department of Sururey, No.3 People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 201900, China.
    • ,
  • Mitsuhiro Inagaki, M.D.

      Affiliations

    • Department of Surgery, Asahikawa Medical College, Japan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, Asahikawa Medical College, Midorigaoka-Higashi 2-1-1-1, Asahikawa, 078-8510 Japan.
    • ,
  • Bojian Jiang, M.D.

      Affiliations

    • Department of Surgery, Asahikawa Medical College, Japan
    • Present address: Department of Sururey, No.3 People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 201900, China.
    • ,
  • Masaaki Miyakoshi, D.D.S.

      Affiliations

    • Department of Pathology, Asahikawa Medical College, Japan
    • ,
  • Jun Arikura, M.D.

      Affiliations

    • Department of Surgery, Asahikawa Medical College, Japan
    • ,
  • Katsuhiro Ogawa, M.D.

      Affiliations

    • Department of Pathology, Asahikawa Medical College, Japan
    • ,
  • Shinichi Kasai, M.D.

      Affiliations

    • Department of Surgery, Asahikawa Medical College, Japan

Received 1 September 2008

References 

  1. Sass DA, Shakil AO. Fulminant hepatic failure. Liver Transpl. 2005;11:594
  2. Riordan SM, Williams R. Acute liver failure: Targeted artificial and hepatocytes-based support of liver regeneration and reversal of multiorgan failure. J Hepatol. 2000;32:63
  3. Mito M, Ebata H, Kusano M, et al. Morphology and function of isolated hepatocytes transplanted into rat spleen. Transplantation. 1979;28:499
  4. Ogawa K, Ohta T, Inagaki M, et al. Identification of F344 rat hepatocytes transplanted within the liver of congenic analbuminemic rats by the polymerase chain reaction. Transplantation. 1993;56:9
  5. Strom SC, Bruzzone P, Cai H, et al. Hepatocyte transplantation: Clinical experience and potential for future use. Cell Transplantation. 2006;15(Suppl 1):S105
  6. Theise ND, Nimmakayalu M, Gardner R, et al. Liver from bone marrow in humans. Hepatology. 2000;32:11
  7. Alison MR, Poulsom R, Jeffery R, et al. Hepatocytes from non-hepatic adult stem cells. Nature. 2000;406:257
  8. Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science. 1999;14:1168
  9. Lagasse E, Connors H, Al-Dhalimy M, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med. 2000;6:1229
  10. Theise ND, Badve S, Saxena R, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000;31:235
  11. Krause DS, Theise ND, Collector MI, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 2001;105:369
  12. Oertel M, Shafritz D. Stem cells, cell transplantation and liver repopulation. Biochim Biophys Acta. 2008;1782:61
  13. Fogt F, Beyser KH, Poremba C, et al. Recipient-derived hepatocytes in liver transplants: A rare event in sex-mismatched transplants. Hepatology. 2002;36:173
  14. Terada N, Hamazaki T, Oka M, et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature. 2002;416:542
  15. Laconi E, Oren R, Mukhopadhy DK, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol. 1998;153:319
  16. Laconi S, Curreli F, Diana S, et al. Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: A kinetic study. J Hepatol. 1999;31:1069
  17. Gordon GJ, Coleman WB, Grisham JW. Temporal analysis of hepatocyte differentiation by small hepatocyte-like progenitor cells during liver regeneration in retrorsine-exposed rats. Am J Pathol. 2000;157:771
  18. Gordon GJ, Coleman WB, Grisham JW. Bax-medicated apoptosis in the livers of rats after partial hepatectomy in the retrorsine model of hepatocellular injury. Hepatology. 2000;32:312
  19. Gordon GJ, Coleman WB, Hixson DC, et al. Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response. Am J Pathol. 2000;156:607
  20. Oren R, Dabeva MD, Petkov PM, et al. Restoration of normal serum albumin levels in Nagase analbuminemic rats by hepatocyte transplantation. Hepatology. 1999;29:75
  21. Dahlke MH, Popp FC, Bahimann FH, et al. Liver regeneration in a retrorsin/CCl4-induced acute liver failure model: Do bone marrow-derived cells contribute?. J Hepatol. 2003;39:365
  22. Menthena A, Deb N, Oertel M, et al. Bone marrow progenitors are not the source of expanding oval cells in injured liver. Stem Cells. 2004;22:1049
  23. Vig P, Russo FP, Edwards RJ, et al. The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice. Hepatology. 2006;43:316
  24. Popp FC, Slowik P, Eggenhofer E, et al. No contribution of multipotent mesenchymal stromal cells to liver regeneration in a rat model of prolonged hepatic injury. Stem Cells. 2007;25:639
  25. Arikura J, Inagaki M, Huiling X, et al. Colonization of albumin-producing hepatocytes derived from transplanted F344 rat bone marrow cells in the liver of congenic Nagase's analbuminemic rats. J Hepatol. 2004;41:215
  26. Huiling X, Inagaki M, Arikura J, et al. Hepatocytes derived from peripheral blood stem cells of granulocyte-colony stimulating factor treated F344 rats in analbuminemic rat livers. J Surg Res. 2004;122:75
  27. Esumi H, Takahashi Y, Sato S, et al. A seven-base pair deletion in an inborn of the albumin gene of analbuminemic rats. Proc Natl Acad Sci USA. 1983;80:95
  28. Berry MM, Friend DS. High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study. J Cell Biol. 1969;43:506
  29. Selzner M, Clavien PA. Failure of regeneration of the steatotic rat liver: Disruption at two different levels in the regeneration pathway. Hepatology. 2000;31:35
  30. Makino R, Sato S, Esumi H, et al. Presence of albumin-positive cells in the liver of analbuminemic rats and their increase on treatment with hepatocarcinogenesis. Jpn J Cancer Res. 1986;77:153
  31. Fang B, Mingxia L, Lianming Y, et al. Systemic infusion of FLK1+ mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation. 2004;78:83
  32. Yannaki E, Althanasiou E, Xagorari A, et al. G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair program. Exp Hematol. 2005;33:108
  33. Cantz T, Sharma AD, Jochheim-Richter A, et al. Re-evaluation of bone marrow-derived cells as a source for hepatocyte regeneration. Cell Transplant. 2004;13:659
  34. Hess D, Li L, Martin M, et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotech. 2003;21:763
  35. Oritz LA, Gambelli F, McBridge C, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA. 2003;100:8407
  36. Silva GV, Litovsky S, Assad JAR, et al. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation. 2005;111:150
  37. Poll DV, Biju P, Cho CH, et al. Mesenchymal stem cell derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology. 2008;47:1634
  38. Kuo TK, Hung SP, Chuang CH, et al. Stem cell therapy for liver disease: Parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology. 2008;134:2111
  39. Mattocks AR. Toxicity of pyrrolizidine alkaloids. Nature. 1968;217:723
  40. Braun K, Degen JL, Sandgren EP. Hepatocyte transplantation in a model of toxine-induced liver disease: Variable therapeutic effect during replacement of damaged parenchyma by donor cells. Nat Med. 2000;6:320
  41. Terai S, Ishikawa T, Omori K, et al. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Stem Cells. 2006;24:2292
  42. Furst G, Schulute am Esch J, Poll LW, et al. Portal vein embolization and autologous CD133+ bone marrow stem cells for liver regeneration. Radiology. 2007;243:171

PII: S0022-4804(08)01567-9

doi: 10.1016/j.jss.2008.12.013

Journal of Surgical Research
Volume 157, Issue 1 , Pages 71-80 , November 2009

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