Journal of Surgical Research
Volume 157, Issue 1 , Pages 43-47 , November 2009

COX-2 Inhibition Improves Immune System Homeostasis and Decreases Liver Damage in Septic Rats

  • Bin Li, M.M.

      Affiliations

    • Department of General Surgery, The First Hospital of Lanzhou University, Gansu, China
    • ,
  • Yu Min Li, Ph.D., M.D.

      Affiliations

    • Department of General Surgery, The First Hospital of Lanzhou University, Gansu, China
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of General Surgery, The First Hospital of Lanzhou University, 1 Donggang West Road, Lanzhou (730000), Gansu, China.
    • ,
  • Xun Li, M.D.

      Affiliations

    • Department of General Surgery, The First Hospital of Lanzhou University, Gansu, China
    • ,
  • Bin Shi, M.D.

      Affiliations

    • Department of General Surgery, The First Hospital of Lanzhou University, Gansu, China
    • ,
  • Ming Yan He, M.M.

      Affiliations

    • Department of General Surgery, The First Hospital of Lanzhou University, Gansu, China
    • ,
  • Xiao Liang Zhu, M.M.

      Affiliations

    • Department of General Surgery, The First Hospital of Lanzhou University, Gansu, China
    • ,
  • Wen Ce Zhou, M.D.

      Affiliations

    • Department of General Surgery, The First Hospital of Lanzhou University, Gansu, China
    • ,
  • Mitchell S. Wachtel, M.D.

      Affiliations

    • University of Alabama at Birmingham, Birmingham, Georgia
    • ,
  • Eldo Frezza, M.D., M.B.A.

      Affiliations

    • University of Alabama at Birmingham, Birmingham, Georgia

Received 2 April 2008

References 

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  2. HongYuan Lin. Sepsis-challenge and strategy. Chin Crit Care Med. 2004;16:325
  3. Yang SH, Kai W. The therapeutics progress of sepsis. Medical Recapitulate. 2002;8:244
  4. Kniss DA. Cyclooxygenase in reproductive medicine and biology. J Soc Gynecol Investig. 1999;6:285
  5. Song AM, Bhagat L, Singh VP, et al. Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 2002;283:G1166
  6. Ethridge RT, Chung DH, Slogoff M, et al. Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology. 2002;123:1311
  7. Ejima K, Layne MD, Carvazal IM, et al. Cyclooxygenase-2 deficient mice are resistant to endotoxin induced inflammation and death. FASEB J. 2003;10:1078
  8. Flammand FJ, Sibbald WJ, Girotti MJ, et al. Pentoxifylline does not prevent microvascular injury in normotensive, septic rats. Crit Care Med. 1995;23:119
  9. Knoferl MW, Diodato MD, Schwacha MG, et al. Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsis. Shock. 2001;16:479
  10. Wenwei Y, Zongguang Z, Youqin C, et al. Effects of cyclooxygenase-2 expression on blood flow in pancreatic microvessels in rats with acute edematous pancreatitis. Chin J Hepatobiliary Surg. 2004;10:252
  11. Yuan LH, Hen S. The new strategy of immune regulation therapy to sepsis. Chin Crit Care Med. 2004;16:67
  12. Oberholzer C, Oberholzer A, Clare-Salzler M, et al. Apoptosis in sepsis: A new target for therapeutic exploration [J]. FASEB J. 2001;15:879
  13. Oberholzer A, Oberholzer C, Moldawer LL. Understanding the role of innate and acquired immunity [J]. Shock. 2001;16:83
  14. Hotchkiss RS, Karl JE. The pathophysiology and treatment of sepsis [J]. N Engl J Med. 2003;348:138
  15. Goldie AS, Fearon KCH, Ross JA, et al. Natural cytokine antagonists and endogenous antiendotoxin core antibodies in sepsis syndrome. JAMA. 1995;274:172
  16. Yokoyama T, Aramaki O, Takayama T, et al. Selective cyclooxygenase 2 inhibitor induces indefinite survival of fully allogeneic cardiac grafts and generates CD4+ regulatory cells [J]. J Thorac Cardiovasc Surg. 2005;130:1167
  17. Rongqian WU, Xuhua S, Yingxin XU, et al. Pro- and anti-inflammatory cytokine genes expression and sepsis induced liver injury in mice. Chin J Gen Surg. 2001;16:103
  18. Knoferl MW, Diodato MD, Schwacha MG, et al. Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsis [J]. Shock. 2001;16:479
  19. Osterberg J, Ljungdahl M, Haglund U. Influence of cyclooxygenase inhibitors on gut immune cell distribution and apoptosis rate in experimental sepsis [J]. Shock. 2006;25:147

PII: S0022-4804(08)01579-5

doi: 10.1016/j.jss.2008.12.020

Journal of Surgical Research
Volume 157, Issue 1 , Pages 43-47 , November 2009

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