Journal of Surgical Research
Volume 159, Issue 1 , Pages 572-581 , March 2010

Preservation Solutions Alter Mrp2-Dependent Bile Flow in Cold Ischemic Rat Livers

  • Shaoguang Sui, M.D.

      Affiliations

    • Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Atsushi Kudo, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    • Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, Tokyo, Japan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    • ,
  • Makoto Suematsu, M.D., Ph.D.

      Affiliations

    • Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, Tokyo, Japan
    • ,
  • Shinji Tanaka, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Noriaki Nakamura, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Koji Ito, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Shigeki Arii, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Received 23 June 2008

References 

  1. Jaeschke H. Preservation injury: Mechanisms, prevention and consequences. J Hepatol. 1996;25:774
  2. Porte RJ, Ploeg RJ, Hansen B, et al. Long-term graft survival after liver transplantation in the UW era: Late effects of cold ischemia and primary dysfunction. European Multicenter Study Group. Transpl Int. 1998;11(Suppl 1):S164
  3. Caldwell-Kenkel JC, Currin RT, Tanaka Y, et al. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology. 1989;10:292
  4. Ferraz-Neto BH, Zurstrassen MP, Hidalgo R, et al. Donor liver dysfunction: Application of a new scoring system to identify the marginal donor. Transplant Proc. 2007;39:2516
  5. Pokorny H, Gruenberger T, Soliman T, et al. Organ survival after primary dysfunction of liver grafts in clinical orthotopic liver transplantation. Transpl Int. 2000;13(Suppl 1):S154
  6. Adam R, Bismuth H, Diamond T, et al. Effect of extended cold ischemia with UW solution on graft function after liver transplantation. Lancet. 1992;340:1373
  7. Stahl JE, Kreke JE, Malek FA, et al. Consequences of cold-ischemia time on primary nonfunction and patient and graft survival in liver transplantation: A meta-analysis. PLoS ONE. 2008;3:e2468
  8. Lee KW, Cameron AM, Maley WR, et al. Factors affecting graft survival after adult/child split-liver transplantation: Analysis of the UNOS/OPTN data base. Am J Transplant. 2008;8:1186
  9. Lemasters JJ, Thurman RG. Reperfusion injury after liver preservation for transplantation. Annu Rev Pharmacol Toxicol. 1997;37:327
  10. Ploeg RJ, D'Alessandro AM, Knechtle SJ, et al. Risk factors for primary dysfunction after liver transplantation—A multivariate analysis. Transplantation. 1993;55:807
  11. Deschenes M, Belle SH, Krom RA, et al. Early allograft dysfunction after liver transplantation: A definition and predictors of outcome. National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database. Transplantation. 1998;66:302
  12. Teoh NC, Hartley J. Modifications to the UW: Simple solutions to the 'sticky' problem of preservation injury in liver transplantation. J Gastroenterol Hepatol. 2007;22:1564
  13. Kudo A, Kashiwagi S, Kajimura M, et al. Kupffer cells alter organic anion transport through multidrug resistance protein 2 in the post-cold ischemic rat liver. Hepatology. 2004;39:1099
  14. Feng XN, Xu X, Zheng SS. Current status and perspective of liver preservation solutions. Hepatobiliary Pancreat Dis Int. 2006;5:490
  15. Testa G, Malago M, Nadalin S, et al. E. Histidine-tryptophan-ketoglutarate versus University of Wisconsin solution in living donor liver transplantation: Results of a prospective study. Liver Transpl. 2003;9:822
  16. Rayya F, Harms J, Martin AP, et al. Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in adult liver transplantation. Transplant Proc. 2008;40:891
  17. Spiegel HU, Schleimer K, Kranz D, et al. Organ preservation with EC, HTK, and UW solutions in orthotopic liver transplantation in syngeneic rats. Part I: Functional parameters. J Invest Surg. 1998;11:49
  18. Chen F, Nakamura T, Wada H. Development of new organ preservation solutions in Kyoto University. Yonsei Med J. 2004;45:1107
  19. Yoshida H, Okuno H, Kamoto T, et al. Comparison of the effectiveness of ET-Kyoto with Euro-Collins and University of Wisconsin solutions in cold renal storage. Transplantation. 2002;74:1231
  20. Nies AT, Keppler D. The apical conjugate efflux pump ABCC2 (MRP2). Pflugers Arch. 2007;453:643
  21. Jedlitschky G, Hoffmann U, Kroemer HK. Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opin Drug Metab Toxicol. 2006;2:351
  22. Gonzalez FX, Rimola A, Grande L, et al. Predictive factors of early postoperative graft function in human liver transplantation. Hepatology. 1994;20:565
  23. Heise M, Settmacher U, Pfitzmann R, et al. A survival-based scoring-system for initial graft function following orthotopic liver transplantation. Transpl Int. 2003;16:794
  24. Williams JW, Vera S, Peters TG, et al. Cholestatic jaundice after hepatic transplantation. A nonimmunologically mediated event. Am J Surg. 1986;151:65
  25. Ban D, Kudo A, Sui S, et al. Decreased Mrp2-dependent bile flow in the post-warm ischemic rat liver. J Surg Res. 2009;153:310
  26. Ismair MG, Stanca C, Ha HR, et al. Interactions of glycyrrhizin with organic anion transporting polypeptides of rat and human liver. Hepatol Res. 2003;26:343
  27. Horikawa M, Kato Y, Tyson CA, et al. The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: Probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. Drug Metab Pharmacokinet. 2002;17:23
  28. Shimamura H, Suzuki H, Tagaya O, et al. Biliary excretion of glycyrrhizin in rats: Kinetic basis for multiplicity in bile canalicular transport of organic anions. Pharm Res. 1996;13:1833
  29. van Rossum TG, Vulto AG, Hop WC, et al. Glycyrrhizin-induced reduction of ALT in European patients with chronic hepatitis C. Am J Gastroenterol. 2001;96:2432
  30. Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases. Dig Liver Dis. 2007;39:293
  31. Ballatorin N, Rebbeor JF. Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione. Semin Liver Dis. 1998;18:377
  32. Lu SC, Kuhlenkamp J, Ge JL, et al. Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver. Mol Pharmacol. 1994;46:578
  33. Suzuki H, Suematsu M, Ishii H, et al. Prostaglandin E1 abrogates early reductive stress and zone-specific paradoxical oxidative injury in hypoperfused rat liver. J Clin Invest. 1994;93:155
  34. Kumamoto Y, Suematsu M, Shimazu M, et al. Kupffer cell-independent acute hepatocellular oxidative stress and decreased bile formation in post-cold-ischemic rat liver. Hepatology. 1999;30:1454
  35. van der Kolk DM, de Vries EG, Noordhoek L, et al. Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia. Leukemia. 2001;15:1544
  36. Mor-Cohen R, Zivelin A, Rosenberg N, et al. Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome. J Biol Chem. 2001;276:36923
  37. Mottino AD, Cao J, Veggi LM, et al. Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide-induced cholestasis. Hepatology. 2002;35:1409
  38. Goda N, Suzuki K, Naito M, et al. Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation. J Clin Invest. 1998;101:604
  39. Kajimura M, Shimoyama M, Tsuyama S, et al. Visualization of gaseous monoxide reception by soluble guanylate cyclase in the rat retina. FASEB J. 2003;17:506
  40. Kubitz R, Wettstein M, Warskulat U, et al. Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology. 1999;116:401
  41. Baumgartner U, Scholmerich J, Kremer B, et al. Early detection of graft dysfunction after orthotopic liver transplantation in man by serum and biliary bile acid analysis. Hepatogastroenterology. 1995;42:950
  42. Friman S, Persson H, Karlberg I, et al. The bile acid independent flow is reduced in the transplanted liver. Transpl Int. 1992;5(Suppl 1):S163

PII: S0022-4804(08)01595-3

doi: 10.1016/j.jss.2008.12.043

Journal of Surgical Research
Volume 159, Issue 1 , Pages 572-581 , March 2010

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