Journal of Surgical Research
Volume 155, Issue 1 , Pages 18-24 , July 2009

Serum from Radiofrequency-Injured Livers Induces Differentiation of Bone Marrow Stem Cells into Hepatocyte-Like Cells

  • Yi Yang, M.D.

      Affiliations

    • Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China
    • ,
  • Bo Qu, Ph.D.

      Affiliations

    • Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China
    • ,
  • Jian-Hua Huo, Ph.D.

      Affiliations

    • Department of Cardiology, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China
    • ,
  • Sheng-Li Wu, Ph.D.

      Affiliations

    • Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China
    • ,
  • Ming-Yu Zhang, Ph.D.

      Affiliations

    • Department of Orthopedics, Second Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China
    • ,
  • Zuo-Ren Wang, M.D., Ph.D.

      Affiliations

    • Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College,Xi'an Jiao Tong University, Xi'an 710061.

Received 29 February 2008

References 

  1. Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science. 1999;284:1168
  2. Sharma AD, Cantz T, Manns MP, et al. The role of stem cells in physiology, pathophysiology, and therapy of the liver. Stem Cell Rev. 2006;2:51
  3. Am Esch JS, Knoefel WT, Klein M, et al. Portal application of autologous CD133+ bone marrow cells to the liver: A novel concept to support hepatic regeneration. Stem Cells. 2005;23:463
  4. Merkle EM, Boll DT, Boaz T, et al. MRI-guided radiofrequency thermal ablation of implanted VX2 liver tumors in a rabbit model: Demonstration of feasibility at 0.2 T. Magn Reson Med. 1999;42:141
  5. Lin SM, Lin CJ, Lin CC, et al. Randomized controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less. Gut. 2005;54:1151
  6. Fang D, Seo BM, Liu Y, et al. Transplantation of mesenchymal stem cells is an optimal approach for plastic surgery. Stem Cells. 2007;25:1021
  7. Mizuno N, Shiba H, Ozeki Y, et al. Human autologous serum obtained using a completely closed bag system as a substitute for fetal calf serum in human mesenchymal stem cell cultures. Cell Biol Int. 2006;30:521
  8. Bruinink A, Tobler U, Halg M, et al. Effects of serum and serum heat-inactivation on human bone derived osteoblast progenitor cells. J Mater Sci Mater Med. 2004;15:497
  9. Qihao Z, Xigu C, Guanghui C, et al. Spheroid formation and differentiation into hepatocyte-like cells of rat mesenchymal stem cell induced by co-culture with liver cells. DNA Cell Biol. 2007;26:497
  10. Bhowmick NA, Chytil A, Plieth D, et al. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science. 2004;303:848
  11. Forte G, Minieri M, Cossa P, et al. Hepatocyte growth factor effects on mesenchymal stem cells: Proliferation, migration, and differentiation. Stem Cells. 2006;24:23
  12. Neuss S, Becher E, Woltje M, et al. Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem Cells. 2004;22:405
  13. Hatch HM, Zheng D, Jorgensen ML, et al. SDF-1alpha/CXCR4: A mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured liver of rats. Cloning Stem Cells. 2002;4:339
  14. Tang LJ, Gao Y, Zhang Z, et al. [Human bone marrow multipotent adult progenitor cells differentiate into hepatocyte-like cells with hepatocyte growth factor plus fibroblast growth factor-4 in vitro]. Zhonghua Gan Zang Bing Za Zhi. 2005;13:652
  15. Theise ND, Nimmakayalu M, Gardner R, et al. Liver from bone marrow in humans. Hepatology. 2000;32:11
  16. Theise ND, Badve S, Saxena R, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000;31:235
  17. Am Esch JS, Knoefel WT, Klein M, et al. Portal application of autologous CD133+ bone marrow cells to the liver: A novel concept to support hepatic regeneration. Stem Cells. 2005;23:463
  18. Mitchell C, Fausto N. Bone marrow - derived hepatocytes: Rare but promising. Am J Pathol. 2002;161:349
  19. Pawliuk R, Westerman KA, Fabry ME, et al. Correction of sickle cell disease in transgenic mouse models by gene therapy. Science. 2001;294:2368

PII: S0022-4804(09)00009-2

doi: 10.1016/j.jss.2009.01.006

Journal of Surgical Research
Volume 155, Issue 1 , Pages 18-24 , July 2009

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