Journal of Surgical Research
Volume 159, Issue 1 , Pages e25-e28 , March 2010

Decrease in Wound Tensile Strength Following Post-Surgical Estrogen Replacement Therapy in Ovariectomized Rats During the Early Phase of Healing is Mediated Via ER-α Rather than ER-β: A Preliminary Report

  • Peter Gál, M.Sc.

      Affiliations

    • Department of Medical Biophysics, Pavol Jozef Šafárik University, Košice, Slovak Republic
    • Department of Pathological Anatomy, University of Veterinary Medicine, Košice, Slovak Republic
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department for Biomedical Research, The East-Slovak Institute for Cardiovascular Diseases, Košice, Slovak Republic.
    • ,
  • Martin Novotný, M.D.

      Affiliations

    • Department of Medical Biophysics, Pavol Jozef Šafárik University, Košice, Slovak Republic
    • ,
  • Tomáš Vasilenko

      Affiliations

    • Department of Medical Biophysics, Pavol Jozef Šafárik University, Košice, Slovak Republic
    • ,
  • Filip Depta

      Affiliations

    • Department of Medical Biophysics, Pavol Jozef Šafárik University, Košice, Slovak Republic
    • ,
  • Igor Šulla, D.V.M., Ph.D.

      Affiliations

    • Department of Histology, University of Veterinary Medicine, Košice, Slovak Republic
    • ,
  • Zoltán Tomori, Ph.D.

      Affiliations

    • Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Košice, Slovak Republic

Received 5 November 2008

References 

  1. Hall G, Philips TJ. Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin. J Am Acad Dermatol. 2005;53:555
  2. Paech K, Webb P, Kuiper GG, et al. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science. 1997;277:1508
  3. Kuiper GG, Carlsson B, Grandien K, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997;138:863
  4. Grohé C, Kahlert S, Löbbert K, et al. Cardiac myocytes and fibroblasts contain functional estrogen receptors. FEBS Lett. 1997;416:107
  5. Lindner V, Kim SK, Karas RH, et al. Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury. Circ Res. 1998;83:224
  6. Thornton MJ. The biological actions of estrogens on skin. Exp Dermatol. 2002;11:487
  7. Lambert KC, Curran EM, Judy BM, et al. Estrogen receptor alpha (ERalpha) deficiency in macrophages results in increased stimulation of CD4 + T cells while 17beta-estradiol acts through ERα to increase IL-4 and GATA-3 expression in CD4+ T cells independent of antigen presentation. J Immunol. 2005;175:5716
  8. Törnwall J, Carey AB, Fox RI, et al. Estrogen in autoimmunity: Expression of estrogen receptors in thymic and autoimmune T cells. J Gend Specif Med. 1999;2:33
  9. Yu HP, Shimizu T, Hsieh YC, et al. Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage. J Leukoc Biol. 2006;79:963
  10. Gál P, Toporcer T, Vidinský B, et al. Postsurgical administration of estradiol benzoate decreases tensile strength of healing skin wounds in ovariectomized rats. J Surg Res. 2008;147:117
  11. Lund TD, Rovis T, Chung WC, et al. Novel actions of estrogen receptor-beta on anxiety-related behaviors. Endocrinology. 2005;146:797
  12. Wegorzewska IN, Walters K, Weiser MJ, et al. Postovariectomy weight gain in female rats is reversed by estrogen receptor alpha agonist, propylpyrazoletriol. Am J Obstet Gynecol. 2008;199:67
  13. Gál P, Tomori Z, Novotný M, et al. Load speed affects the values of skin wound strength measured by a newly developed highly sensitive testing device. Lékař a technika. 2008;38:85
  14. Gál P, Toporcer T, Vidinský B, et al. Early changes in the tensile strength and morphology of primary sutured skin wounds in rats. Folia Biol (Prague). 2006;52:109
  15. Gál P, Vidinský B, Toporcer T, et al. Histologic assessment of the effect of laser irradiation on skin wound healing in rats. Photomed Laser Surg. 2006;24:480
  16. Miller VM, Duckles SP. Vascular actions of estrogens: Functional implications. Pharmacol Rev. 2008;60:210
  17. Grandas OH, Mountain DJ, Kirkpatrick SS, et al. Effect of hormones on matrix metalloproteinases gene regulation in human aortic smooth muscle cells. J Surg Res. 2008;148:94
  18. Song RX, Zhang Z, Chen Y, et al. Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells. Endocrinology. 2007;148:4091
  19. Merlo S, Frasca G, Canonico PL, et al. Differential involvement of ERα and ERβ in the healing promoting effect of estrogen in human keratinocytes. J Endocrinol. 2009;200:189
  20. Ravanti L, Häkkinen L, Larjava H, et al. Transforming growth factorβ induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase. J Biol Chem. 1999;274:37292

PII: S0022-4804(09)00081-X

doi: 10.1016/j.jss.2009.02.024

Journal of Surgical Research
Volume 159, Issue 1 , Pages e25-e28 , March 2010

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