Journal of Surgical Research
Volume 159, Issue 1 , Pages 603-610 , March 2010

Carnitine Protects the Intestine Against Reperfusion Injury in Rats

  • Ferda Ulviye Hosgorler, M.D.

      Affiliations

    • Department of Surgery, Dokuz Eylul University, School of Medicine, Izmir, Turkey
    • ,
  • Koray Atila, M.D.

      Affiliations

    • Department of Surgery, Dokuz Eylul University, School of Medicine, Izmir, Turkey
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, Dokuz Eylul University, School of Medicine, Korutürk Mahallesi Kauçuk Sokak No:5 D:15, Balçova Izmir 35330, Turkey.
    • ,
  • Cem Terzi, M.D.

      Affiliations

    • Department of Surgery, Dokuz Eylul University, School of Medicine, Izmir, Turkey
    • ,
  • Serpil Tanriverdi Akhisaroglu, M.D.

      Affiliations

    • Department of Biochemistry, Dokuz Eylul University, School of Medicine, Izmir, Turkey
    • ,
  • Gulgun Oktay, M.D.

      Affiliations

    • Department of Biochemistry, Dokuz Eylul University, School of Medicine, Izmir, Turkey
    • ,
  • Ali Kupelioglu, M.D.

      Affiliations

    • Department of Pathology, Dokuz Eylul University, School of Medicine, Izmir, Turkey
    • ,
  • Gul Ergor, M.D.

      Affiliations

    • Department of Public Health and Biostatistics, Dokuz Eylul University, School of Medicine, Izmir, Turkey
    • ,
  • Serdar Saydam, M.D.

      Affiliations

    • Department of Surgery, Dokuz Eylul University, School of Medicine, Izmir, Turkey

Received 16 October 2008

References 

  1. Zimmermann BJ, Granger DN. Intestinal ischemia: Reperfusion injury. Surg Clin North Am. 1992;72:65
  2. Schmeling D, Caty M, Oldham T, et al. Cytoprotection by Diclofenac Sodium after intestinal ischemia/reperfusion injury. J Pediatr Surg. 1994;29:1044
  3. Langer J, Sohal S, Marshall J. Histamine does not mediate mucosal permeability changes after subclinical intestinal ischemia-reperfusion injury. J Pediatr Surg. 1993;28:1113
  4. Parks DA, Granger N. Contributions of ischemia and reperfusion to mucosal lesion formation. Am J Physiol. 1986;250:749
  5. Terzi C, Kuzu MA, Aşlar K, et al. Prevention of deleterious effects of reperfusion injury using one-week high dose Allopurinol. Dig Dis Sci. 2001;46:430
  6. Posma LAE, Bleichrodt RP, Goor HV, et al. Transient profound mesenteric ischemia strongly affects the strength of intestinal anastomoses in the rat. Dis Colon Rectum. 2007;50:1070
  7. Megison SM, Horton JW, Chao H, et al. A new model for intestinal ischemia in the rat. Jour Surg Res. 1990;49:168
  8. Barroso-Aranda J, Schmid-Schönbein GW, Zweifach B. Granulocytes and no-reflow phenomenon in irreversible hemorrhagic shock. Circ Res. 1988;63:437
  9. Siliprandi N, Sartorelli L, Ciman M, et al. Carnitine: Metabolism and clinical chemistry. Clin Chim Acta. 1989;183:3
  10. Hoppel C. The physiological role of carnitine. In:  Ferrari R,  Di Mauro S,  Sherwood G editor. L-Carnitine and its role in medicine: From function to therapy. New York: Academic Press; 1999;p. 5–20
  11. Rizzon P, Biasco G, Di Biase M, et al. High doses of L-carnitine acute myocardial infarction: Metabolic and antiarrhythmic affects. Eur Heart J. 1989;10:502
  12. Packer L, Valenza M, Serbinova E, et al. Free radical scavenging is involved in the protective effect of L-propionyl-carnitine against ischemia-reperfusion injury of the heart. Arch Biochem Biophys. 1991;288:533
  13. Atila K, Coker A, Sagol O, et al. I. Protective effects of carnitine in an experimental ischemia-reperfusion injury. Clin Nutr. 2002;21:309
  14. Schinetti ML, Mazzini A. Effect of L-carnitine on human neutrophil activity. Int J Tissue React. 1986;8:199
  15. Stroh R, Christopher T, Lopez B, et al. L-Propionyl Carnitine, an endogenous ester in fatty acid metabolism, exerts anti-shock and endothelial protective effects in rat splanchnic ischemia-reperfusion injury. Shock. 1998;9:216
  16. Chiu CJ, Mc Ardle AH, Brown R, et al. Intestinal mucosal lesions in low-flow states. A morphologic, hemodynamic, and metabolic reappraisal. Arch Surg. 1970;101:478
  17. Kurtel H, Granger DN, Tso P, et al. Vulnerability of intestinal interstitial fluid to oxidant stress. Am J Physiol. 1992;263:573
  18. Angel MF, Ramasastry SS, Swartz WM, et al. The critical relationship between free radicals and degrees of ischemia: Evidence for tissue intolerance of marginal perfusion. Plast Reconstr Surg. 1988;81:233
  19. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem. 1990;36:1440
  20. Irvin TT, Hunt TK. Reappraisal of the healing process of anastomoses of the colon. Surg Gynecol Obstet. 1974;138:741
  21. Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem. 1996;29:225
  22. de Roy van Zuidewijn DB, Schillings PH, Wobbes T, et al. Histological evaluation of wound healing in experimental intestinal anastomoses: Effects of antineoplastic agents. Int J Exp Pathol. 1992;73:465
  23. Megison SM, Horton JW, Chao H, et al. Prolonged survival and decreased mucosal injury after low dose enteral Allopurinol prophylaxis in mesenteric ischemia. Jour Surg Res. 1990;25:917
  24. Brown M, Ross A, Dasher J, et al. The role of leukocytes in mediating mucosal injury of intestinal ischemia/reperfusion. J Pediatr Surg. 1990;25:214
  25. Windsor ACJ, Mullen PG, Fowler AA, et al. Role of the neutrophil in adult respiratory distress syndrome. Br J Surg. 1993;80:10
  26. Mollace V, Iannone M, Muscoli C, et al. The protective affect of M40401 a superoxide dismutase mimetic, on post ischemic brain damage in mongolian gerbils. BMC Pharmacol. 2003;3:8
  27. Simşek A, Yagci G, Zeybek N, et al. Effects of portal triad occlusion on left sided colonic anastomosis. Int Surg. 2002;87:25
  28. Grace PA. Ischemia-reperfusion injury. Br J Surg. 1994;81:637
  29. Most D, Efron DT, Shi HP, et al. Characterization of incisional wound healing in inducible nitric oxide synthase knockout mice. Surgery. 2002;132:866
  30. Aguilar-Nascimento JE, Mathie RT. Enhanced intra-anastomotic healing by operative lavage with nutrient solutions in experimental left sided colonic obstruction. Br J Surg. 1995;82:461
  31. Gottrup F. Oxygen, wound healing and the development of infection. Present status. Eur J Surg. 2002;168:260
  32. Junge K, Klinde U, Klosterhalfen B, et al. Review of healing with reference to an unrepairable abdominal hernia. Eur J Surg. 2002;168:67
  33. Dimitrijevich SD, Paranjape S, Wilson JR, et al. Effect of hyperbaric oxygen on human skin cells in culture and human dermal and skin equivalents. Wound Repair Regen. 1999;7:53

PII: S0022-4804(09)00110-3

doi: 10.1016/j.jss.2009.03.028

Journal of Surgical Research
Volume 159, Issue 1 , Pages 603-610 , March 2010

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