Journal of Surgical Research
Volume 159, Issue 1 , Pages 474-481 , March 2010

Identification of a Novel Potential Biomarker in a Model of Hemorrhagic Shock and Valproic Acid Treatment1

  • Yongqing Li, M.D., Ph.D.

      Affiliations

    • Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts
    • These two authors contributed equally to the work.
    • ,
  • Baoling Liu, M.D.

      Affiliations

    • Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts
    • These two authors contributed equally to the work.
    • ,
  • Simon T. Dillon, Ph.D.

      Affiliations

    • Genomics and Proteomics Core at Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • ,
  • Eugene Y. Fukudome, M.D.

      Affiliations

    • Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Tareq Kheirbek, M.D.

      Affiliations

    • Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Elizabeth A. Sailhamer, M.D.

      Affiliations

    • Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • George Velmahos, M.D., Ph.D.

      Affiliations

    • Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Marc deMoya, M.D.

      Affiliations

    • Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Towia A. Libermann, Ph.D.

      Affiliations

    • Genomics and Proteomics Core at Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    • ,
  • Hasan B. Alam, M.D.

      Affiliations

    • Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, 165 Cambridge Street, Suite 810, Boston, MA 02114.

Received 9 January 2009

References 

  1. Sun S, Lee NPY, Poon RTP, et al. Oncoproteomics of hepatocellular carcinoma: From cancer markers' discovery to functional pathways. Liver Int. 2007;27:1021
  2. Hergenroeder G, Redell J, Moore AN, et al. Identification of serum biomarkers in brain-injured adults: Potential for predicting elevated intracranial pressure. J Neurotrauma. 2008;25:79
  3. Voshol H, Brendlen N, Muller D, et al. Evaluation of biomarker discovery approaches to detect protein biomarkers of acute renal allograft rejection. J Proteome Res. 2005;4:1192
  4. Hodgetts A, Levin M, Kroll JS, et al. Biomarker discovery in infectious disease using SELDI. Future Microbiol. 2007;2:35
  5. Hortin GL. The MALDI-TOF mass spectrometric view of the plasma proteome and peptidome. Clin Chem. 2006;52:1223
  6. Aggarwal K, Choe LH, Lee KH. Shotgun proteomics using the iTRAQ isobaric tags. Brief Funct Genomic Proteomic. 2006;5:112
  7. Engwegen JY, Gast MC, Schellens JH, et al. Clinical proteomics: Searching for better tumor makers with SELDI-TOF mass spectrometry. Trends Pharmacol Sci. 2006;27:251
  8. Shults C, Sailhamer EA, Li Y, et al. Surviving blood loss without fluid resuscitation. J Trauma. 2008;64:629
  9. Li Y, Liu B, Sailhamer EA, et al. Cell protective mechanism of valproic acid in lethal hemorrhagic shock. Surgery. 2008;144:217
  10. Thuijls G, deHaan JJ, Derikx JP, et al. Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock. Shock. 2009;31:164
  11. Chen SP, Zhou B, Wills BC, et al. Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol. 2005;98:322
  12. Wong V, Gumbiner BM. A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J Cell Biol. 1997;136:399
  13. Rahner C, Mitic LL, Anderson JM. Heterogeneity in expression and subcellular localization of claudin 2, 3, 4, and 5 in the rat liver, pancreases, and gut. Gastroenterology. 2001;120:411
  14. Li Q, Zhang Q, Wang C, et al. Effect of n-3 polyunsaturated fatty acids on membrane microdomain localization of tight junction proteins in experimental colitis. FEBS J. 2008;275:411
  15. Ivanov AI, Nusrat A, Parkos CA. Endocytosis of the apical junctional complex: Mechanisms and possible roles in regulation of epithelial barriers. BioEssays. 2005;27:356
  16. Wolbrug H, Wolburg-Buchholz K, Kraus J, et al. Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol. 2003;105:586
  17. Krizbal IA, Lenzser G, Szatmari E, et al. Blood-brain barrier changes during compensated and decompensated hemorrhagic shock. Shock. 2005;24:428
  18. Honda H, Pazin MJ, D'Souza T, et al. Regulation of the CLDN3 gene in ovarian cancer cells. Cancer Biol Ther. 2007;6:1733

PII: S0022-4804(09)00197-8

doi: 10.1016/j.jss.2009.04.011

Journal of Surgical Research
Volume 159, Issue 1 , Pages 474-481 , March 2010

Article Tools

* Image Usage & Resolution