Journal of Surgical Research
Volume 159, Issue 1 , Pages 468-473 , March 2010

A Different View of Lactate in Trauma Patients: Protecting the Injured Brain

  • Elizabeth L. Cureton, M.D.

      Affiliations

    • Department of Surgery, University of California San Francisco-East Bay, Alameda County Medical Center, Oakland, California
    • ,
  • Rita O. Kwan, M.D., M.P.H.

      Affiliations

    • Department of Surgery, University of California San Francisco-East Bay, Alameda County Medical Center, Oakland, California
    • ,
  • Kristopher C. Dozier, M.D.

      Affiliations

    • Department of Surgery, University of California San Francisco-East Bay, Alameda County Medical Center, Oakland, California
    • ,
  • Javid Sadjadi, M.D.

      Affiliations

    • Department of Surgery, University of California San Francisco-East Bay, Alameda County Medical Center, Oakland, California
    • ,
  • Jay D. Pal, M.D., Ph.D.

      Affiliations

    • Department of Surgery, Duke University, Durham, North Carolina
    • ,
  • Gregory P. Victorino, M.D.

      Affiliations

    • Department of Surgery, University of California San Francisco-East Bay, Alameda County Medical Center, Oakland, California
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, University of California San Francisco-East Bay, Alameda County Medical Center, UCSF-East Bay, 1411 East 31st Street, Oakland, CA 94602.

Received 9 January 2009

References 

  1. Cohen R, Woods H. Clinical and biochemical aspects of lactic acidosis. Oxford: Blackwell; 1976;
  2. Pal JD, Victorino GP, Twomey P, et al. Admission serum lactate levels do not predict mortality in the acutely injured patient. J Trauma. 2006;60:583
  3. Nedergaard M, Goldman S. Carrier-mediated transport of lactic acid in cultured neurons and astrocytes. Am J Physiol. 1993;265:R282
  4. Lin B, Busto R, Globus M, et al. Brain temperature modulations during global ischemia fail to influence extracellular lactate levels in rats. Stroke. 1995;26:1634
  5. De Salles A, Muizelaar J, Young H. Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. Neurosurgery. 1987;21:45
  6. De Salles A, Kontos H, Becker D, et al. Prognostic significance of ventricular CSF lactic acidosis in severe head injury. J Neurosurg. 1986;65:615
  7. Tsacopoulos M, Magistretti PJ. Metabolic coupling between glia and neurons. J Neurosci. 1996;16:877
  8. Schurr A, West CA, Rigor BM. Lactate-supported synaptic function in the rat hippocampal slice preparation. Science. 1988;240:1326
  9. Levasseur JE, Alessandri B, Reinert M, et al. Lactate, not glucose, up-regulates mitochondrial oxygen consumption both in sham and lateral fluid percussed rat brains. Neurosurgery. 2006;59:1122
  10. Larrabee MG. Lactate metabolism and its effects on glucose metabolism in an excised neural tissue. J Neurochem. 1995;64:1734
  11. Cerdan S, Rodrigues TB, Sierra A, et al. The redox switch/redox coupling hypothesis. Neurochemistry international. 2006;48:523
  12. Schurr A, Rigor BM. Brain anaerobic lactate production: A suicide note or a survival kit?. Developmental neuroscience. 1998;20:348
  13. Schurr A, Payne RS, Miller JJ, et al. Glia are the main source of lactate utilized by neurons for recovery of function posthypoxia. Brain Res. 1997;774:221
  14. Schurr A, Payne RS, Miller JJ, et al. Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia. Brain Res. 2001;895:268
  15. Chen T, Qian YZ, Di X, et al. Lactate/glucose dynamics after rat fluid percussion brain injury. J Neurotrauma. 2000;17:135
  16. Chen T, Qian YZ, Rice A, et al. Brain lactate uptake increases at the site of impact after traumatic brain injury. Brain Res. 2000;861:281
  17. Rice AC, Zsoldos R, Chen T, et al. Lactate administration attenuates cognitive deficits following traumatic brain injury. Brain Res. 2002;928:156
  18. Holloway R, Zhou Z, Harvey HB, et al. Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat. Acta Neurochir (Wien). 2007;149:919;discussion 927
  19. Glenn TC, Kelly DF, Boscardin WJ, et al. Energy dysfunction as a predictor of outcome after moderate or severe head injury: Indices of oxygen, glucose, and lactate metabolism. J Cereb Blood Flow Metab. 2003;23:1239
  20. Perel P, Edwards P, Shakur H, et al. Use of the Oxford Handicap Scale at hospital discharge to predict Glasgow Outcome Scale at 6 months in patients with traumatic brain injury. BMC Med Res Methodol. 2008;8:72
  21. Hanks R, Millis S, Ricker J, et al. The predictive validity of a brief inpatient neuropsychological battery for persons with traumatic brain injury. Arch Phys Med Rehab. 2008;89:950
  22. Corral L, Ventura J, Herrero J, et al. Improvement in GOS and GOSE scores 6 and 12 months after severe traumatic brain injury. Brain Inj. 2007;21:1225
  23. Millis S, Rosenthal M, Novack T, et al. Long-term neuropsychological outcome after traumatic brain injury. J Head Trauma Rehab. 2001;16:343
  24. Inao S, Marmarou A, Clarke G, et al. Production and clearance of lactate from brain tissue, cerebrospinal fluid, and serum following experimental brain injury. J Neurosurg. 1988;69:736

PII: S0022-4804(09)00214-5

doi: 10.1016/j.jss.2009.04.020

Journal of Surgical Research
Volume 159, Issue 1 , Pages 468-473 , March 2010

Article Tools

* Image Usage & Resolution