Journal of Surgical Research
Volume 158, Issue 1 , Pages 10-14 , January 2010

In Vitro Activation of Human Peripheral Blood Mononuclear Cells Induced by Human Biologic Meshes1

  • Sean Orenstein, M.D.

      Affiliations

    • Connecticut Comprehensive Center for Hernia Repair, Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut
    • ,
  • Yi Qiao, M.D.

      Affiliations

    • Center for Molecular Tissue Engineering, Department of Surgery, University of Connecticut School of Medicine, Farmington, Connecticut
    • ,
  • Manjot Kaur, B.S.

      Affiliations

    • Center for Molecular Tissue Engineering, Department of Surgery, University of Connecticut School of Medicine, Farmington, Connecticut
    • ,
  • Ulrike Klueh, Ph.D.

      Affiliations

    • Connecticut Comprehensive Center for Hernia Repair, Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut
    • Center for Molecular Tissue Engineering, Department of Surgery, University of Connecticut School of Medicine, Farmington, Connecticut
    • ,
  • Don Kreutzer, Ph.D.

      Affiliations

    • Connecticut Comprehensive Center for Hernia Repair, Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut
    • Center for Molecular Tissue Engineering, Department of Surgery, University of Connecticut School of Medicine, Farmington, Connecticut
    • ,
  • Yuri Novitsky, M.D.

      Affiliations

    • Connecticut Comprehensive Center for Hernia Repair, Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue–MC 3955, Farmington, Connecticut 06030.

References 

  1. Gray SH, Hawn MT, Itani KM. Surgical progress in inguinal and ventral incisional hernia repair. Surg Clin North Am. 2008;88:17
  2. Rutkow IM. Demographic and socioeconomic aspects of hernia repair in the United States in 2003. Surg Clin North Am. 2003;83:1045
  3. Jin J, Rosen MJ, Blatnik J, et al. Use of acellular dermal matrix for complicated ventral hernia repair: Does technique affect outcomes?. J Am Coll Surg. 2007;205:654
  4. Bachman S, Ramshaw B. Prosthetic material in ventral hernia repair: How do I choose?. Surg Clin North Am. 2008;88:101
  5. Milburn ML, Holton LH, Chung TL, et al. Acellular dermal matrix compared with synthetic implant material for repair of ventral hernia in the setting of perioperative Staphylococcus aureus implant contamination: A rabbit model. Surg Infect (Larchmt). 2008;9:433
  6. Schuster R, Singh J, Safadi BY, et al. The use of acellular dermal matrix for contaminated abdominal wall defects: Wound status predicts success. Am J Surg. 2006;192:594
  7. Shaikh FM, Giri SK, Durrani S, et al. Experience with porcine acellular dermal collagen implant in one-stage tension-free reconstruction of acute and chronic abdominal wall defects. World J Surg. 2007;31:1966;discussion 1973
  8. Badylak SF. Xenogeneic extracellular matrix as a scaffold for tissue reconstruction. Transpl Immunol. 2004;12:367
  9. Badylak SF, Valentin JE, Ravindra AK, et al. Macrophage phenotype as a determinant of biologic scaffold remodeling. Tissue Eng Part A. 2008;14:1835
  10. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5:953
  11. Schachtrupp A, Klinge U, Junge K, et al. Individual inflammatory response of human blood monocytes to mesh biomaterials. Br J Surg. 2003;90:114
  12. Schutte RJ, Parisi-Amon A, Reichert WM. Cytokine profiling using monocytes/macrophages cultured on common biomaterials with a range of surface chemistries. J Biomed Mater Res A. 2009;88:128
  13. Kaback LA, Smith TJ. Expression of hyaluronan synthase messenger ribonucleic acids and their induction by interleukin-1β in human orbital fibroblasts: Potential insight into the molecular pathogenesis of thyroid-associated ophthalmopathy. J Clin Endocrinol Metab. 1999;84:4079
  14. Oncul O, Yildiz S, Gurer US, et al. Effect of the function of polymorphonuclear leukocytes and interleukin-1β on wound healing in patients with diabetic foot infections. J Infect. 2007;54:250
  15. Yamada Y, Itano N, Hata K, et al. Differential regulation by IL-1beta and EGF of expression of three different hyaluronan synthases in oral mucosal epithelial cells and fibroblasts and dermal fibroblasts: Quantitative analysis using real-time RT-PCR. J Invest Dermatol. 2004;122:631
  16. Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials. 2006;27:3675
  17. Badylak SF, Gilbert TW. Immune response to biologic scaffold materials. Semin Immunol. 2008;20:109
  18. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8:958

PII: S0022-4804(09)00289-3

doi: 10.1016/j.jss.2009.05.033

Journal of Surgical Research
Volume 158, Issue 1 , Pages 10-14 , January 2010

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