Journal of Surgical Research
Volume 167, Issue 2 , Pages e365-e373 , 15 May 2011

Hypothermic Machine Preservation Attenuates Ischemia/Reperfusion Markers After Liver Transplantation: Preliminary Results

  • James V. Guarrera, M.D., F.A.C.S.

      Affiliations

    • Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, 622 West 168th Street PH 14 Center, Room 202, New York, NY 10032.
    • ,
  • Scot D. Henry, Ph.D.

      Affiliations

    • Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York
    • ,
  • Sean W.C. Chen, M.S.

      Affiliations

    • Department of Anesthesiology, Columbia University Medical Center, New York, New York
    • ,
  • Tod Brown, B.S.

      Affiliations

    • Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York
    • ,
  • Eugenia Nachber, M.A.

      Affiliations

    • Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York
    • ,
  • Ben Arrington, B.S.

      Affiliations

    • Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York
    • ,
  • Jason Boykin

      Affiliations

    • Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York
    • ,
  • Benjamin Samstein, M.D.

      Affiliations

    • Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York
    • ,
  • Robert S. Brown Jr., M.D., M.P.H.

      Affiliations

    • Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York
    • ,
  • Jean C. Emond, M.D.

      Affiliations

    • Department of Surgery, Center for Liver Disease and Transplantation, Columbia University Medical Center, New York
    • ,
  • H. Thomas Lee, M.D., Ph.D.

      Affiliations

    • Department of Anesthesiology, Columbia University Medical Center, New York, New York

Received 5 December 2009

References 

  1. Fuller B, Dijk S, Butler P, et al. Pro-inflammatory agents accumulate during donor liver cold preservation: A study on increased adhesion molecule expression and abrogation by curcumin in cultured endothelial cells. Cryobiology. 2003;46:284
  2. Llacuna L, Mari M, Lluis JM, et al. Reactive oxygen species mediate liver injury through parenchymal nuclear factor-κB inactivation in prolonged ischemia/reperfusion. Am J Pathol. 2009;174:1776
  3. Kokura S, Yoshida N, Yoshikawa T. Anoxia/reoxygenation-induced leukocyte-endothelial cell interactions. Free Radic Biol Med. 2002;33:427
  4. Dutkowski P, Graf R, Clavien PA. Rescue of the cold preserved rat liver by hypothermic oxygenated machine perfusion. Am J Transplant. 2006;6(5 Pt 1):903
  5. Guarrera JV, Karim NA. Liver preservation: Is there anything new yet?. Curr Opin Organ Transplant. 2008;13:148
  6. Maheshwari A, Maley W, Li Z, et al. Biliary complications and outcomes of liver transplantation from donors after cardiac death. Liver Transpl. 2007;13:1645
  7. Ploeg RJ, D'Alessandro AM, Knechtle SJ, et al. Risk factors for primary dysfunction after liver transplantation–A multivariate analysis. Transplantation. 1993;55:807
  8. Kwiatkowski A, Wszola M, Kosieradzki M, et al. Machine perfusion preservation improves renal allograft survival. Am J Transplant. 2007;7:1942
  9. Matsuoka L, Shah T, Aswad S, et al. Pulsatile perfusion reduces the incidence of delayed graft function in expanded criteria donor kidney transplantation. Am J Transplant. 2006;6:1473
  10. Moers C, Smits JM, Maathuis MH, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med. 2009;360:7
  11. Schold JD, Kaplan B, Howard RJ, et al. Are we frozen in time? Analysis of the utilization and efficacy of pulsatile perfusion in renal transplantation. Am J Transplant. 2005;5:1681
  12. Guarrera JV, Henry SD, Samstein B, et al. Hypothermic machine preservation in human liver transplantation: The first clinical series. Am J Transplant. 2010;10:372
  13. Guarrera JV, Estevez J, Boykin J, et al. Hypothermic machine perfusion of liver grafts for transplantation: Technical development in human discard and miniature swine models. Transplant Proc. 2005;37:323
  14. Menger MD. Microcirculatory disturbances secondary to ischemia-reperfusion. Transplant Proc. 1995;27:2863
  15. Stansby G, Fuller B, Jeremy J, et al. Endothelin release–A facet of reperfusion injury in clinical liver transplantation?. Transplantation. 1993;56:239
  16. Bosma BM, Metselaar HJ, Mancham S, et al. Characterization of human liver dendritic cells in liver grafts and perfusates. Liver Transpl. 2006;12:384
  17. Bessems M, Doorschodt BM, Kolkert JL, et al. Preservation of steatotic livers: A comparison between cold storage and machine perfusion preservation. Liver Transpl. 2007;13:497
  18. Dutkowski P, Furrer K, Tian Y, et al. Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. Ann Surg. 2006;244:968;discussion 76
  19. Iwamoto H, Matsuno N, Narumi Y, et al. Beneficial effect of machine perfusion preservation on liver transplantation from non-heart-beating donors. Transplant Proc. 2000;32:1645

PII: S0022-4804(10)00090-9

doi: 10.1016/j.jss.2010.01.038

Journal of Surgical Research
Volume 167, Issue 2 , Pages e365-e373 , 15 May 2011

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