Journal of Surgical Research
Volume 171, Issue 1 , Pages 114-119 , November 2011

VEGF Modulates Angiogenesis and Osteogenesis in Shockwave-Promoted Fracture Healing in Rabbits

  • Ching-Jen Wang, M.D.

      Affiliations

    • Department of Orthopedic Surgery, Chang Gung University College of Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung, Taiwan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, 123 Ta-Pei Road, Niao-Sung Hsing, Kaohsiung, Taiwan 833.
  • ,
  • Ko-En Huang, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung, Taiwan
  • ,
  • Yi-Chih Sun, B.A.

      Affiliations

    • Department of Medical Research, Chang Gung University College of Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung, Taiwan
  • ,
  • Ya-Ju Yang, B.A.

      Affiliations

    • Department of Medical Research, Chang Gung University College of Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung, Taiwan
  • ,
  • Jih-Yang Ko, M.D.

      Affiliations

    • Department of Orthopedic Surgery, Chang Gung University College of Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung, Taiwan
  • ,
  • Lin-Hsiu Weng, M.D.

      Affiliations

    • Department of Orthopedic Surgery, Chang Gung University College of Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung, Taiwan
  • ,
  • Feng-Sheng Wang, Ph.D.

      Affiliations

    • Department of Medical Research, Chang Gung University College of Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung, Taiwan

Received 18 November 2009

References 

  1. Wang CJ, Huang HY, Chen HS, et al. The effect of shock wave therapy on acute fractures of the tibia. A study in a dog model. Clin Orthop. 2001;387:112
  2. Romp JD, Rosendahl T, Schollner C, et al. High-energy extracorporeal shock wave treatment of nonunions. Clin Orthop. 2001;387:102
  3. Wang CJ, Chen HS, Chen CE, et al. Treatment of non-union fracture of the long bone with shock waves. Clin Orthop. 2001;387:95
  4. Maier M, Milz S, Tischer T, et al. Influence of extracorporeal shock-wave application on normal bone in an animal model in vivo. J Bone Joint Surg Br. 2002;84B:592
  5. Wang CJ, Huang HY, Pai CH. Shockwave enhances neovascularization at the tendon-bone junction. J Foot Ankle Surg. 2002;44:16
  6. Wang CJ, Wang FS, Yang KD, et al. Shock wave therapy induces neovascularization at the tendon-bone junction. A study in rabbits. J Orthop Res. 2003;21:984
  7. Hausman MR, Schaffler MB, Majeska RJ. Prevention of fracture healing in rats by an inhibitor of angiogenesis. Bone. 2001;29:560
  8. Uchida S, Sakai A, Kudo H, et al. Vascular endothelial growth factor is expressed along with its receptors during the healing process of bone and bone marrow after drill-hole injury in rats. Bone. 2003;32:491
  9. Hankemeier S, Grassel G, Plenz A, et al. Alteration of fracture stability influences chondrogenesis, osteogenesis and immigration of macophages. J Orthop Res. 2001;19:531
  10. Tasuyama K, Maezawa Y, Baba H, et al. Expression of various growth factors for cell population and cytodifferentiation during fracture repair of bone. Eur J Histochem. 2000;44:269
  11. Boyan BD, Calpan AI, Heckman JD, et al. Osteochondral progenitor cells in are acute and chronic canine nonunions. J Orthop Res. 1999;17:246
  12. Hayda RA, Brighton CT, Esterhai JL. Pathophysiology of delayed healing. Clin Orthop Res. 1999;355S:7
  13. Elhorm TA, Majeska RJ, Rush EB, Levine PM, Horowitz MC. The expression of cytokines activity by fracture callus. J Bone Miner Res. 1995;10:1272
  14. Rosier RN, O'Keefe RJ, Hicks DG. The potential role of transforming growth factor in fracture healing. Clin Orthop. 1998;355:294
  15. Azuma Y, Kaji K, Katogi R, et al. Tumor necrosis factor-αinduces differentiation of bone resorption by osteoclast. J Biol Chem. 2000;275:4858
  16. Eckardt H, Bundgaard KG, Christensen KS, et al. Effect of locally applied vascular endothelial growth factor (VEGF) and VEGF inhibitor to the rabbit tibia during distraction osteogenesis. J Orthop Res. 2003;21:335
  17. Peng H, Wright V, Usas A, et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest. 2002;110:751
  18. Tarkka T, Sipola A, Jamsa T, et al. Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues. J Gene Med. 2003;5:560
  19. Salter DM, Wallace WHB, Robb JE, et al. Human bone cell hyperpolarization response to cyclic mechanical strain is mediated by an interleukin-1b autocrine/paracrine loop. J Bone Miner Res. 2001;15:1746
  20. Chen YJ, Kuo YR, Yang KD, et al. Activation of extracellular signal-regulated kinase (ERK) and p38 kinase in shock wave-promoted bone formation of segmental defect in rats. Bone. 2004;34:466
  21. Takahashi K, Yamazaki M, Saisu T, et al. Gene expression for extracellular matrix proteins in shockwave-induced osteogenesis in rats. Calcif Tissue Int. 2004;74:187
  22. Hietaniemi H, Peltonen J, Paavolainen P. An experimental model for non-union in rats. Injury. 1995;26:681
  23. Moore DC, Leblanc CW, Muller R, et al. Physiologic weight-bearing increases new vessel formation during distraction osteogenesis: A micro-tomographic imaging study. J Orthop Res. 2003;21:489
  24. Moralli MR, Caldwell NJ, Patil PV, et al. An in vivo model for investigation of mechanical signal transduction in trabecular bone. J Bone Miner Res. 2000;15:1346
  25. Stefanadis C, Toutouzas K, Stefanadi E, et al. Inhibition of plaque neovascularization and intimal hyperplasia by specific targeting vascular endothelial growth factor with bevacizumab-eluting stent: An experimental study. Atherosclerosis. 2007;195:269
  26. Bakri SJ, Snyder MR, Reid JM, et al. Pharmacokinetics of intravitreal bevacizumab (Avastin). Ophthalmology. 2007;114:855
  27. Papathanassiou M, Theodossiadis PG, Liarakos VS, et al. Inhibition of corneal neovascularization by subconjunctival bevacizumab in an animal model. Am J Ophthalmol. 2008;145:424

PII: S0022-4804(10)00095-8

doi: 10.1016/j.jss.2010.01.045

Journal of Surgical Research
Volume 171, Issue 1 , Pages 114-119 , November 2011