Journal of Surgical Research
Volume 171, Issue 1 , Pages 234-239 , November 2011

Effect of TachoSil in a Coagulopathic Pig Model with Blunt Liver Injuries

  • Oliver Grottke

      Affiliations

    • Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany
    • Institute for Laboratory Animal Science, RWTH Aachen University Hospital, Aachen, Germany
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Anesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany.
    • Oliver Grottke and Till Braunschweig contributed equally to this article.
    • ,
  • Till Braunschweig

      Affiliations

    • Department of Pathology, RWTH Aachen University Hospital, Aachen, Germany
    • Oliver Grottke and Till Braunschweig contributed equally to this article.
    • ,
  • Nora Daheim

      Affiliations

    • Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany
    • ,
  • Marc Coburn

      Affiliations

    • Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany
    • ,
  • Gerrit Grieb

      Affiliations

    • Department of Plastic Surgery and Hand Surgery, RWTH Aachen University Hospital, Aachen, Germany
    • ,
  • Rolf Rossaint

      Affiliations

    • Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany
    • ,
  • Rene Tolba

      Affiliations

    • Institute for Laboratory Animal Science, RWTH Aachen University Hospital, Aachen, Germany

Received 16 November 2009

References 

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  2. Spahn DR, Rossaint R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth. 2005;95:130
  3. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: A review of mechanisms. J Trauma. 2008;65:748
  4. Spahn DR, Cerny V, Coats TJ, et al. Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: A European guideline. Crit Care. 2007;11:R17
  5. Rickenbacher A, Breitenstein S, Lesurtel M, et al. Efficacy of TachoSil a fibrin-based hemostat in different fields of surgery—a systematic review. Expert Opin Biol Ther. 2009;9:897
  6. Frilling A, Stavrou GA, Mischinger HJ, et al. Effectiveness of a new carrier-bound fibrin sealant versus argon beamer as haemostatic agent during liver resection: A randomized prospective trial. Langenbecks Arch Surg. 2005;390:114
  7. Siemer S, Lahme S, Altziebler S, et al. Efficacy and safety of TachoSil as haemostatic treatment versus standard suturing in kidney tumor resection: A randomized prospective study. Eur Urol. 2007;52:1156
  8. Anegg U, Lindenmann J, Matzi V, et al. Efficiency of fleece-bound sealing (TachoSil) of air leaks in lung surgery: A prospective randomized trial. Eur J Cardiothorac Surg. 2007;31:198
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  13. Grottke O, Braunschweig T, Phillipen B, et al. A new model for blunt liver injuries in the swine. Eur Surg Res. 2010;44:65
  14. Velik-Salchner C, Schnürer C, Fries D, et al. Normal values for thromboelastography and selected coagulation parameters in porcine blood. Thromb Res. 2006;35:310
  15. Tyburski JG, Wilson RF, Dente C, et al. Factors affecting mortality rates in patients with abdominal vascular injuries. J Trauma. 2001;50:1020
  16. Rossaint R, Cerny V, Coats TJ, et al. Key issues in advanced bleeding care in trauma. Shock. 2006;26:322
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  18. Holcomb JB, Pusateri AE, Harris RA, et al. Effect of dry fibrin sealant dressings versus gauze packing on blood loss in grade V liver injuries in resuscitated swine. J Trauma. 1999;46:49
  19. Holcomb JB, Pusateri AE, Harris RA, et al. Dry fibrin sealant dressings reduce blood loss, resuscitation volume, and improve survival in hypothermic coagulopathic swine with grade V liver injuries. J Trauma. 1999;47:233
  20. Erdogan D, de Graaf W, van Gulik TM. Adhesive strength of fibrinogen-coated collagen patch or liquid fibrin sealant in an experimental liver resection model in pigs. Eur Surg Res. 2008;41:298
  21. Sondeen JL, Pusateri AE, Coppes VG, et al. Comparison of 10 different hemostatic dressings in an aortic injury. J Trauma. 2003;54:280
  22. Pusateri AE, Holcomb JB, Harris RA, et al. Effect of fibrin bandage fibrinogen concentration on blood loss after grade V liver injury in swine. Mil Med. 2001;166:217
  23. Pusateri AE, Modrow HE, Harris RA, et al. Advanced hemostatic dressing development program: Animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in Swine. J Trauma. 2003;55:518

PII: S0022-4804(10)00098-3

doi: 10.1016/j.jss.2010.02.002

Journal of Surgical Research
Volume 171, Issue 1 , Pages 234-239 , November 2011

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