Journal of Surgical Research
Volume 166, Issue 2 , Pages 255-264, April 2011

Upper Gastrointestinal Carcinogenesis: H. pylori and Stem Cell Cross-Talk

  • Ioannis Pilpilidis, M.D.

      Affiliations

    • Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece
    • ,
  • Jannis Kountouras, M.D., Ph.D.

      Affiliations

    • Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, 8 Fanariou St., Byzantio, 551 33, Thessaloniki, Macedonia, Greece.
    • ,
  • Christos Zavos, M.D.

      Affiliations

    • Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece
    • ,
  • Panagiotis Katsinelos, M.D., Ph.D.

      Affiliations

    • Department of Endoscopy and Motility Unit, Central Hospital, Thessaloniki, Greece

Received 2 November 2009 published online 08 March 2010.

Chronic inflammation of the gastric epithelium has been associated with the pathogenesis of gastric cancer, as it was postulated by Corea's model of gastric carcinogenesis. Helicobacter pylori (Hp) regulates this inflammatory process and promotes gastric carcinogenesis through induction of gene mutations and protein modulation. Recent data raise the cancer stem cell hypothesis, which implies a central role of multipotent cancer cells in oncogenesis of various solid tumors. This review provides a synopsis of gastric cancer initiation and promotion through Hp and stem cell signaling pathways. The expanding research field of Hp-related cancer stem cell biology may offer novel implications for future treatment of upper gastrointestinal cancer.

Key Words: gastric carcinogenesis, oncogenic signaling pathways, bone marrow-derived stem cells, epithelial cancer

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PII: S0022-4804(10)00108-3

doi:10.1016/j.jss.2010.02.012

Journal of Surgical Research
Volume 166, Issue 2 , Pages 255-264, April 2011

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