Journal of Surgical Research
Volume 168, Issue 2 , Pages 179-187 , 15 June 2011

Glucose-Induced Intestinal Vasodilation Via Adenosine A1 Receptors Requires Nitric Oxide but Not K+ATP Channels

  • Paul J. Matheson, Ph.D.

      Affiliations

    • Department of Surgery, University of Louisville, Louisville, Kentucky
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Surgery, University of Louisville, ACB 2nd Floor, Louisville, KY 40292.
    • ,
  • Na Li, M.D.

      Affiliations

    • Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky
    • ,
  • Patrick D. Harris, Ph.D.

      Affiliations

    • Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky
    • ,
  • El Rasheid Zakaria, M.D., Ph.D.

      Affiliations

    • Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky
    • ,
  • R. Neal Garrison, M.D.

      Affiliations

    • Department of Surgery, University of Louisville, Louisville, Kentucky
    • Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky
    • Louisville Veterans Affairs Medical Center, Louisville, Kentucky

Received 8 June 2009

References 

  1. Burnstock G. Current state of purinoceptor research. Pharm Acta Helv. 1995;69:231
  2. Granger HJ, Norris CP. Role of adenosine in local control of intestinal circulation in the dog. Circ Res. 1980;46:764
  3. Proctor KG. Possible role for adenosine in local regulation of absorptive hyperemia in rat intestine. Circ Res. 1986;59:474
  4. Proctor KG. Intestinal arteriolar responses to mucosal and serosal applications of adenosine analogues. Circ Res. 1987;61:187
  5. Bivalacqua TJ, Champion HC, Lambert DG, et al. Vasodilator responses to adenosine and hyperemia are mediated by A1 and A2 receptors in the cat vascular bed. Am J Physiol Regulatory Integrative Comp Physiol. 2002;282:R1696
  6. Bryan PT, Marshall JM. Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: A role for A1 receptors. J Physiol. 1999;514:151
  7. Danialou G, Vicaut E, Sambe A, et al. Predominant role of A1 adenosine receptors in mediating adenosine induced vasodilatation of rat diaphragmatic arterioles: Involvement of nitric oxide and the ATP-dependent K+ channels. Br J Pharmacol. 1997;121:1355
  8. Li N, Harris PD, Zakaria el R, Matheson PJ, et al. Microvascular responses to adenosine help explain functional and pathologic differences between intestinal segments. Am J Surg. 2004;188:526
  9. Hinschen AK, Rose'Meyer RB, Headrick JP. Adenosine receptor subtypes mediating coronary vasodilation in rat hearts. J Cardiovasc Pharmacol. 2003;41:73
  10. Ngai AC, Coyne EF, Meno JR, et al. Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles. Am J Physiol Heart Circ Physiol. 2001;280:H2329
  11. Hein TW, Belardinelli L, Kuo L. Adenosine A(2A) receptors mediate coronary microvascular dilation to adenosine: Role of nitric oxide and ATP-sensitive potassium channels. J Pharmacol Exp Ther. 1999;291:655
  12. Bohlen HG, Lash JM. Intestinal absorption of sodium and nitric oxide-dependent vasodilation interact to dominate resting vascular resistance. Circ Res. 1996;78:231
  13. Bohlen HG. Mechanism of increased vessel wall nitric oxide concentrations during intestinal absorption. Am J Physiol. 1998;275(2 Pt 2):H542
  14. Maher MM, Gontarek JD, Jimenez RE, et al. Endogenous nitric oxide promotes ileal absorption. J Surg Res. 1995;58:687
  15. Abebe W, Hussain T, Olanrewaju H, et al. Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery. Am J Physiol Heart Circ Physiol. 1995;269:H1672
  16. Ali S, Metzger WJ, Olanrewaju HA, et al. Adenosine receptor-mediated relaxation of rabbit airway smooth muscle: A role for nitric oxide. Am J Physiol. 1997;273(3 Pt 1):L581
  17. Li J, Fenton RA, Wheeler HB, et al. Adenosine A2a receptors increase arterial endothelial cell nitric oxide. J Surg Res. 1998;80:357
  18. Nieri P, Martinotti E, Calderone V, et al. Adenosine-mediated hypotension in in vivo guinea-pig: Receptors involved and role of NO. Br J Pharmacol. 2001;134:745
  19. Matheson PJ, Wilson MA, Spain DA, et al. Glucose-induced intestinal hyperemia is mediated by nitric oxide. J Surg Res. 1997;72:146
  20. Bohlen HG, Gore RW. Preparation of rat intestinal muscle and mucosa for quantitative microcirculatory studies. Microvasc Res. 1976;11:103
  21. Matheson PJ, Wilson MA, Garrison RN. Regulation of intestinal blood flow. J Surg Res. 2000;93:182
  22. Dorner GT, Garhofer G, Kiss B, et al. Nitric oxide regulates retinal vascular tone in humans. Am J Physiol Heart Circ Physiol. 2003;285:H631
  23. Fernandez N, Sanchez MA, Martinez MA, et al. Role of nitric oxide in vascular tone and in reactivity to isoproterenol and adenosine in the goat coronary circulation. Eur J Pharmacol. 2000;387:93
  24. Matheson PJ, Spain DA, Harris PD, et al. Glucose and glutamine gavage increase portal vein nitric oxide metabolite levels via adenosine A2b activation. J Surg Res. 1999;84:57
  25. Weisbrodt NW, Pressley TA, Li YF, et al. Decreased ileal muscle contractility and increased NOS II expression induced by lipopolysaccharide. Am J Physiol. 1996;271(3 Pt 1):G454
  26. Chou CC, Hsieh CP, Yu YM, et al. Localization of mesenteric hyperemia during digestion in dogs. Am J Physiol. 1976;230:583
  27. Gallavan RH, Chou CC, Kvietys PR, et al. Regional blood flow during digestion in the conscious dog. Am J Physiol. 1980;238:H220
  28. Sawmiller DR, Chou CC. Role of adenosine in postprandial and reactive hyperemia in canine jejunum. Am J Physiol. 1992;263(4 Pt 1):G487
  29. Li Q, Puro DG. Adenosine activates ATP-sensitive K(+) currents in pericytes of rat retinal microvessels: Role of A1 and A2a receptors. Brain Res. 2001;907:93
  30. Rubio R, Ceballos G. Sole activation of three luminal adenosine receptor subtypes in different parts of coronary vasculature. Am J Physiol Heart Circ Physiol. 2003;284:H204
  31. Sterin-Borda L, Gomez RM, Borda E. Role of nitric oxide/cyclic GMP in myocardial adenosine A1 receptor-inotropic response. Br JPharmacol. 2002;135:444
  32. Kirsch GE, Codina J, Birnbaumer L, et al. Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes. Am J Physiol. 1990;259(3 Pt 2):H820
  33. Mubagwa K, Flameng W. Adenosine, adenosine receptors and myocardial protection: An updated overview. Cardiovasc Res. 2001;52:25
  34. Kubo M, Nakaya Y, Matsuoka S, et al. Atrial natriuretic factor and isosorbide dinitrate modulate the gating of ATP-sensitive K+ channels in cultured vascular smooth muscle cells. Circ Res. 1994;74:471
  35. Yao Z, Gross GJ. Glibenclamide antagonizes adenosine A1 receptor-mediated cardioprotection in stunned canine myocardium. Circulation. 1993;88:235
  36. Tabrizchi R, Lupichuk SM. Vasodilatation produced by adenosine in isolated rat perfused mesenteric artery: A role for endothelium. Naunyn Schmiedebergs Arch Pharmacol. 1995;352:412
  37. Linden J. Structure and function of A1 adenosine receptors. FASEB J. 1991;5:2668
  38. Murthy KS, McHenry L, Grider JR, et al. Adenosine A1 and A2b receptors coupled to distinct interactive signaling pathways in intestinal muscle cells. J Pharmacol Exp Ther. 1995;274:300
  39. Chou CC, Alemayehu A, Mangino MJ. Prostanoids in regulation of postprandial jejunal hyperemia and oxygen uptake. Am J Physiol. 1989;257(5 Pt 1):G798

PII: S0022-4804(10)00109-5

doi: 10.1016/j.jss.2010.02.013

Journal of Surgical Research
Volume 168, Issue 2 , Pages 179-187 , 15 June 2011

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