Journal of Surgical Research
Volume 163, Issue 1 , Pages e1-e9 , September 2010

Cardiomyocytic Apoptosis Limited by Bradykinin via Restoration of Nitric Oxide after Cardioplegic Arrest

  • Chi-Hsiao Yeh, M.D., Ph.D.

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan
    • College of Medicine, Chang Gung University, Tauyuan, Taiwan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Keelung, 222 Mai-Chin Road, Keelung 204, Taiwan.
  • ,
  • Tzu-Ping Chen, M.D.

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan
  • ,
  • Yao-Chang Wang, M.D.

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan
  • ,
  • Yu-Min Lin, M.S.

      Affiliations

    • College of Medicine, Chang Gung University, Tauyuan, Taiwan
  • ,
  • Shu-Wen Fang, B.S.

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan

Received 23 December 2009

References 

  1. Taylor KM, Bain WH, Morton JJ. The role of angiotensin II in the development of peripheral vasoconstriction during open-heart surgery. Am Heart J. 1980;100:935
  2. Engelman DT, Watanabe M, Engelman RM, et al. Constitutive nitric oxide release is impaired after ischemia and reperfusion. J Thorac Cardiovasc Surg. 1995;110:1047
  3. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333:664
  4. Andrási TB, Soós P, Bakos G, et al. L-arginine protects the mesenteric vascular circulation against cardiopulmonary bypass-induced vascular dysfunction. Surgery. 2003;134:72
  5. Valen G. The basic biology of apoptosis and its implications for cardiac function and viability. Ann Thorac Surg. 2003;75:S656
  6. Kuwahara K, Saito Y, Kishimoto I, et al. Cardiotrophin-1 phosphorylates Akt and Bad, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes. J Mol Cell Cardiol. 2000;32:13854
  7. Yeh CH, Lin YM, Wu YC, et al. Nitric oxide attenuates cardiomyocytic apoptosis via diminished mitochondrial complex I up-regulation from cardiac ischemia-reperfusion injury under cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2004;128:180
  8. Ho FM, Lin WW, Chen BC, et al. High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF- κB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway. Cell Signal. 2006;18:391
  9. Yeh CH, Chen TP, Wu YC, et al. Inhibition of NFκB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. J Surg Res. 2005;125:109
  10. Goto M, Liu Y, Yang XM, et al. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ Res. 1995;77:611
  11. Kono Y, Sawada S, Kawahara T, et al. Bradykinin inhibits serum-depletion-induced apoptosis of human vascular endothelial cells by inducing nitric oxide via calcium ion kinetics. J Cardiovasc Pharmacol. 2002;39:251
  12. Yeh CH, Chen TP, Lee CH, et al. Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor-alpha but not gamma activators. Shock. 2006;26:262
  13. Chen BC, Yu CC, Lei HC, et al. Bradykinin B2 receptor mediates NF- κB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells. J Immunol. 2004;173:5219
  14. Fischer UM, Klass O, Stock U, et al. Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes. Eur J Cardiothorac Surg. 2003;23:984
  15. Depre C, Wang L, Sui X, et al. H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart. Circ Res. 2006;98:280
  16. Communal C, Sumandea M, de Tombe P, et al. Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci USA. 2002;99:6252
  17. Patel JM, Zhang J, Block ER. Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: Role of thioredoxin in regulation of catalytic activity. Am J Respir Cell Mol Biol. 1996;15:410
  18. Bell RM, Yellon DM. Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: The role of PI3K, Akt, and eNOS. J Mol Cell Cardiol. 2002;35:185
  19. Massoudy P, Becker BF, Gerlach E. Bradykinin accounts for improved postischemic function and decreased glutathione release of guinea pig heart treated with the angiotensin-converting enzyme inhibitor ramiprilat. J Cardiovasc Pharmacol. 1994;23:632
  20. Linz W, Wiemer G, Gohlke P, et al. Contribution of kinins to the cardiovascular action of angiotensin converting enzyme inhibitors. Pharmacol Rev. 1995;47:25
  21. Kaiserova K, Tang X-L, Srivastava S, et al. Role of nitric oxide in regulating aldose reductase activation in the ischemic heart. J Biol Chem. 2008;283:9101
  22. Gao F, Gao E, Yue T-L, et al. Nitric oxide mediates the anti-apoptotic effect of insulin in myocardial ischemia-reperfusion: The roles of PI3-Kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation. 2002;105:1497
  23. Hengartner MO. The biochemistry of apoptosis. Nature. 2000;407:770
  24. Kharbandra S, Pandey P, Schofield L, et al. Role of Bcl-xL as an inhibitor of cytosolic cytochrome c accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci USA. 1997;94:6939

PII: S0022-4804(10)00318-5

doi: 10.1016/j.jss.2010.04.005

Journal of Surgical Research
Volume 163, Issue 1 , Pages e1-e9 , September 2010