Journal of Surgical Research
Volume 163, Issue 1 , Pages 12-17 , September 2010

Validation of Plasma Biomarkers in Degenerative Calcific Aortic Stenosis

  • Giovanni Ferrari, Ph.D.

      Affiliations

    • Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, 500 S. Ridgeway Ave, Room 257, Glenolden, PA 19036.
    • ,
  • Rachana Sainger, Ph.D.

      Affiliations

    • Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
    • ,
  • Erik Beckmann, M.D.

      Affiliations

    • Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
    • ,
  • Gianluca Keller

      Affiliations

    • Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
    • ,
  • Pey-Jen Yu, M.D.

      Affiliations

    • New York University School of Medicine, Department of Cardiothoracic Surgery, New York University School of Medicine New York, New York
    • ,
  • Maria Cristina Monti, Ph.D.

      Affiliations

    • Department of Biostatistics, Columbia University, New York, New York
    • ,
  • Aubrey C. Galloway, M.D.

      Affiliations

    • New York University School of Medicine, Department of Cardiothoracic Surgery, New York University School of Medicine New York, New York
    • ,
  • Richard L. Weiss, M.D.

      Affiliations

    • Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
    • ,
  • William Vernick, M.D.

      Affiliations

    • Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
    • ,
  • Juan B. Grau, M.D.

      Affiliations

    • Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania

Received 8 January 2010

References 

  1. Freeman RV, Otto CM. Spectrum of calcific aortic valve disease: Pathogenesis, disease progression, and treatment strategies. Circulation. 2005;111:3316
  2. Goldbarg SH, Elmariah S, Miller MA, et al. Insights into degenerative aortic valve disease. J Am Coll Cardiol. 2007;50:1205
  3. Bach DS, Radeva JI, Birnbaum HG, et al. Prevalence, referral patterns, testing, and surgery in aortic valve disease: Leaving women and elderly patients behind?. J Heart Valve Dis. 2007;16:362–369
  4. Cowell SJ, Newby DE, Boon NA, et al. Calcific aortic stenosis: Same old story?. Age Ageing. 2004;33:5384
  5. Balmer C, Beghetti M, Fasnacht M, et al. Balloon aortic valvoplasty in paediatric patients: Progressive aortic regurgitation is common. Heart. 2004;90:77
  6. O'Brien KD. Pathogenesis of calcific aortic valve disease: A disease process comes of age (and a good deal more). Arterioscler Thromb Vasc Biol. 2006;26:1721
  7. Gottdiener JS, Bednarz J, Devereux R, et al. American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr. 2004;17:1086
  8. Rosenhek R, Binder T, Porenta G, et al. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med. 2000;343:611
  9. Price PA, Lim JE. The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex. J Biol Chem. 2003;278:22144
  10. Straumann E, Meyer B, Misteli M, et al. Aortic and mitral valve disease in patients with end stage renal failure on long-term haemodialysis. Br Heart J. 1992;67:236
  11. Novaro GM, Aronow HD, Mayer-Sabik E, et al. Plasma homocysteine and calcific aortic valve disease. Heart. 2004;90:802
  12. Gunduz H, Arine H, tamer A, et al. The relationship between homomcysteine and calcific aortic valve stenosis. Cardiology. 2005;103:207
  13. Cho HJ, Cho HJ, Kim HS. Osteopontin: A multifunctional protein at the crossroads of inflammation, atherosclerosis, and vascular calcification. Curr Atheroscler Rep. 2009;11:206
  14. Jeevanantham V, Singh N, Izuora K, et al. Correlation of high sensitivity C-reactive protein and calcific aortic valve disease. Mayo Clin Proc. 2007;82:171
  15. Ross J, Braunwald E. Aortic stenosis. Circulation. 1968;38:61–67
  16. Atalar E, Ozturk E, Ozer N, et al. Plasma soluble osteopontin concentrations are increased in patients with rheumatic mitral stenosis and associated with the severity of mitral valve calcium. Am J Cardiol. 2006;98:817
  17. Yu PJ, Skolnick A, Ferrari G, et al. Correlation between plasma osteopontin levels and aortic valve calcification: Potential insights into the pathogenesis of aortic valve calcification and stenosis. J Thorac Cardiovasc Surg. 2009;138:196
  18. Bergler-Klein J. Natriuretic peptides in the management of aortic stenosis. Curr Cardiol Rep. 2009;11:85
  19. Spargias K, Alexopoulos E, Thomopoulou S, et al. Effect of balloon valvuloplasty in patients with severe aortic stenosis on levels of N-terminal pro-B-type natriuretic peptide. Am J Cardiol. 2009;15:846
  20. Orlowska-Baranowska E, Baranowski R, Greszata L, et al. Brain natriuretic peptide as a marker of left ventricular hypertrophy in patients with aortic stenosis. J Heart Valve Dis. 2008;17:598
  21. Ix JH, Chertow GM, Shlipak MG, et al. Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: Data from the Heart and Soul Study. Circulation. 2007;115:2533

PII: S0022-4804(10)00358-6

doi: 10.1016/j.jss.2010.04.010

Journal of Surgical Research
Volume 163, Issue 1 , Pages 12-17 , September 2010

Article Tools

* Image Usage & Resolution