Journal of Surgical Research
Volume 172, Issue 1 , Pages 68-76 , January 2012

Surgical Thoracic Sympathectomy Induces Structural and Biomechanical Remodeling of the Thoracic Aorta in a Porcine Model

  • Dimitrios C. Angouras, M.D.

      Affiliations

    • Athens University School of Medicine, Attikon University Hospital, Department of Cardiac Surgery, Athens, Greece
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of Cardiac Surgery, Attikon University Hospital, 1 Rimini Street, Chaidari, 12462, Athens, Greece.
    • ,
  • Theodosios J. Dosios, M.D.

      Affiliations

    • Athens University School of Medicine, Attikon University Hospital, Department of Cardiac Surgery, Athens, Greece
    • ,
  • Constantinos A. Dimitriou, M.Sc.

      Affiliations

    • Academy of Athens, Biomedical Research Foundation, Center for Experimental Surgery, Athens, Greece
    • ,
  • Themistocles P. Chamogeorgakis, M.D.

      Affiliations

    • Athens University School of Medicine, Attikon University Hospital, Department of Cardiac Surgery, Athens, Greece
    • ,
  • Chris K. Rokkas, M.D.

      Affiliations

    • Athens University School of Medicine, Attikon University Hospital, Department of Cardiac Surgery, Athens, Greece
    • ,
  • Themistoklis A. Manos, M.Sc.

      Affiliations

    • Academy of Athens, Biomedical Research Foundation, Center for Experimental Surgery, Athens, Greece
    • ,
  • Dimitrios P. Sokolis, Ph.D.

      Affiliations

    • Academy of Athens, Biomedical Research Foundation, Center for Experimental Surgery, Athens, Greece

Received 21 April 2010 ,Accepted 16 July 2010.

References 

  1. Belz GG. Elastic properties and Windkessel function of the human aorta. Cardiovasc Drugs Ther. 1995;9:73
  2. Kassab GS. Biomechanics of the cardiovascular system: The aorta as an illustratory example. J R Soc Interface. 2006;3:719
  3. Failla M, Grappiolo A, Emanuelli G, et al. Sympathetic tone restrains arterial distensibility of healthy and atherosclerotic subjects. J Hypertens. 1999;17:1117
  4. Sonesson B, Vernersson E, Hansen F, et al. Influence of sympathetic stimulation on the mechanical properties of the aorta in humans. Acta Physiol Scand. 1997;159:139
  5. Sokolis DP, Kefaloyannis EM, Kouloukoussa M, et al. A structural basis for the aortic stress-strain relation in uniaxial tension. J Biomech. 2006;39:1651
  6. Sokolis DP. Passive mechanical properties and structure of the aorta: Segmental analysis. Acta Physiol (Oxf). 2007;190:277
  7. Lydakis C, Momen A, Blaha C, et al. Changes of elastic properties of central arteries during acute static exercise and lower body negative pressure. Eur J Appl Physiol. 2008;102:633
  8. Bevan RD. Trophic effects of peripheral adrenergic nerves on vascular structure. Hypertension. 1984;6:III19
  9. Damon DH. Sympathetic innervation promotes vascular smooth muscle differentiation. Am J Physiol Heart Circ Physiol. 2005;288:H2785
  10. Smith PG, Venkataraman P, Reddy H. Smooth muscle growth in the mature rat: Role of sympathetic innervation. J Auton Nerv Syst. 1990;31:13
  11. Yamori Y, Mano M, Nara Y, et al. Catecholamine-induced polyploidization in vascular smooth muscle cells. Circulation. 1987;75:I92
  12. Wolinsky H, Glagov S. Structural basis for the static mechanical properties of the aortic media. Circ Res. 1964;14:400
  13. Sokolis DP, Boudoulas H, Karayannacos PE. Assessment of the aortic stress-strain relation in uniaxial tension. J Biomech. 2002;35:1213
  14. Fronek K, Bloor CM, Amiel D, et al. Effect of long-term sympathectomy on the arterial wall in rabbits and rats. Exp Mol Pathol. 1978;28:279
  15. Lacolley P, Glaser E, Challande P, et al. Structural changes and in situ aortic pressure-diameter relationship in long-term chemical-sympathectomized rats. Am J Physiol. 1995;269:H407
  16. Kingma R, TenVoorde BJ, Scheffer GJ, et al. Thoracic sympathectomy: Effects on hemodynamics and baroreflex control. Clin Auton Res. 2002;12:35
  17. Nakamura Y, Yoshizawa H, Hirasawa M, et al. Effect of endoscopic transthoracic sympathectomy on plasma natriuretic peptide concentrations in humans. Circ J. 2005;69:1079
  18. Chou SH, Kao EL, Lin CC, et al. Sympathetic hypertensive syndrome: A possible surgically curable type of hypertension. Hypertens Res. 2005;28:409
  19. Fridez P, Zulliger M, Bobard F, et al. Geometrical, functional, and histomorphometric adaptation of rat carotid artery in induced hypertension. J Biomech. 2003;36:671
  20. Matsumoto T, Hayashi K. Mechanical and dimensional adaptation of rat aorta to hypertension. J Biomech Eng. 1994;116:278
  21. Ben DA, Benessiano J, Poitevin P, et al. Arterial expansive remodeling induced by high flow rates. Am J Physiol. 1997;272:H851
  22. Guzman RJ, Krystkowiak A, Zarins CK. Early and sustained medial cell activation after aortocaval fistula creation in mice. J Surg Res. 2002;108:112
  23. Dimitriadou V, Aubineau P, Taxi J, et al. Ultrastructural changes in the cerebral artery wall induced by long-term sympathetic denervation. Blood Vessels. 1988;25:122
  24. Kacem K, Sercombe C, Hammami M, et al. Sympathectomy causes aggravated lesions and dedifferentiation in large rabbit atherosclerotic arteries without involving nitric oxide. J Vasc Res. 2006;43:289

PII: S0022-4804(10)00637-2

doi: 10.1016/j.jss.2010.07.039

Journal of Surgical Research
Volume 172, Issue 1 , Pages 68-76 , January 2012

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