Journal of Surgical Research
Volume 172, Issue 1 , Pages 165-176 , January 2012

Heparin-Binding EGF-Like Growth Factor Protects Pericytes from Injury

Received 30 June 2010 ,Accepted 28 July 2010.

References 

  1. Mehta VB, Besner GE. HB-EGF promotes angiogenesis in endothelial cells via PI3-kinase and MAPK signaling pathways. Growth Factors (Chur, Switzerland). 2007;25:253
  2. El-Assal ON, Paddock H, Marquez A, et al. Heparin-binding epidermal growth factor-like growth factor gene disruption is associated with delayed intestinal restitution, impaired angiogenesis, and poor survival after intestinal ischemia in mice. J Pediatr Surg. 2008;43:1182
  3. El-Assal ON, Radulescu A, Besner GE. Heparin-binding EGF-like growth factor preserves mesenteric microcirculatory blood flow and protects against intestinal injury in rats subjected to hemorrhagic shock and resuscitation. Surgery. 2007;142:234
  4. Yu X, Radulescu A, Zorko N, et al. Heparin-binding EGF-like growth factor increases intestinal microvascular blood flow in necrotizing enterocolitis. Gastroenterology. 2009;137:221
  5. Zhou Y, Brigstock D, Besner GE. Heparin-binding EGF-like growth factor is a potent dilator of terminal mesenteric arterioles. Microvasc Res. 2009;78:78
  6. Hirschi KK, D’Amore PA. Pericytes in the microvasculature. Cardiovascular research. 1996;32:687
  7. Majno G, Palade GE, Schoefl GI. Studies on inflammation. II. The site of action of histamine and serotonin along the vascular tree: A topographic study. J Biophys Biochem Cytol. 1961;11:607
  8. Maxwell DS, Kruger L. Small blood vessels and the origin of phagocytes in the rat cerebral cortex following heavy particle irradiation. Exp Neurol. 1965;12:33
  9. Herman IM, D’Amore PA. Microvascular pericytes contain muscle and nonmuscle actins. J Cell Biol. 1985;101:43
  10. DeNofrio D, Hoock TC, Herman IM. Functional sorting of actin isoforms in microvascular pericytes. J Cell Biol. 1989;109:191
  11. Tilton RG, Kilo C, Williamson JR. Pericyte-endothelial relationships in cardiac and skeletal muscle capillaries. Microvasc Res. 1979;18:325
  12. Kelley C, D’Amore P, Hechtman HB, et al. Vasoactive hormones and cAMP affect pericyte contraction and stress fibers in vitro. J Muscle Res Cell Motil. 1988;9:184
  13. Haefliger IO, Zschauer A, Anderson DR. Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway. Invest Ophthalmol Vis Sci. 1994;35:991
  14. Besner G, Higashiyama S, Klagsbrun M. Isolation and characterization of a macrophage-derived heparin-binding growth factor. Cell regulation. 1990;1:811
  15. Higashiyama S, Abraham JA, Miller J, et al. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science (New York, N.Y. 1991;251:936
  16. Beerli RR, Hynes NE. Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities. J Biol Chem. 1996;271:6071
  17. Elenius K, Paul S, Allison G, et al. Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J. 1997;16:1268
  18. Nishi E, Prat A, Hospital V, et al. N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. EMBO J. 2001;20:3342
  19. Hospital V, Prat A. Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation. Protein Peptide Lett. 2004;11:501
  20. Iivanainen E, Nelimarkka L, Elenius V, et al. Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor. FASEB J. 2003;17:1609
  21. Yoshizumi M, Kourembanas S, Temizer DH, et al. Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells. J Biol Chem. 1992;267:9467
  22. Fujiyama S, Matsubara H, Nozawa Y, et al. Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. Circ Res. 2001;88:22
  23. Mehta VB, Zhou Y, Radulescu A, et al. HB-EGF stimulates eNOS expression and nitric oxide production and promotes eNOS dependent angiogenesis. Growth Factors (Chur, Switzerland). 2008;26:301
  24. Darland DC, D’Amore PA. TGF beta is required for the formation of capillary-like structures in three-dimensional co-cultures of 10T1/2 and endothelial cells. Angiogenesis. 2001;4:11
  25. Darland DC, Massingham LJ, Smith SR, et al. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol. 2003;264:275
  26. Hirschi KK, Rohovsky SA, D’Amore PA. PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J Cell Biol. 1998;141:805
  27. Dohgu S, Takata F, Yamauchi A, et al. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res. 2005;1038:208
  28. Hall AP. Review of the pericyte during angiogenesis and its role in cancer and diabetic retinopathy. Toxicol Pathol. 2006;34:763
  29. Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circulation research. 2005;97:512
  30. Betsholtz C, Lindblom P, Bjarnegard M, et al. Role of platelet-derived growth factor in mesangium development and vasculopathies: Lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice. Curr Opin Nephrol Hypertens. 2004;13:45
  31. Kale S, Hanai J, Chan B, et al. Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression. FASEB J. 2005;19:270
  32. Joyce NC, Haire MF, Palade GE. Contractile proteins in pericytes. I. Immunoperoxidase localization of tropomyosin. J Cell Biol. 1985;100:1379
  33. Wille KH, Schnorr B. [The occurrence of hemodynamic effective elements in the intestinal blood vessel system]. Anat Histol Embryol. 2003;32:94
  34. Hashimoto K, Higashiyama S, Asada H, et al. Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. J Biol Chem. 1994;269:20060
  35. Davis-Fleischer KM, Besner GE. Structure and function of heparin-binding EGF-like growth factor (HB-EGF). Front Biosci. 1998;3:d288
  36. Feng J, El-Assal ON, Besner GE. Heparin-binding EGF-like growth factor (HB-EGF) and necrotizing enterocolitis. Semin Ped Surg. 2005;14:167
  37. Swinscoe JC, Carlson EC. Capillary endothelial cells secrete a heparin-binding mitogen for pericytes. J Cell Sci. 1992;103(Pt 2):453
  38. Michalsky MP, Kuhn A, Mehta V, et al. Heparin-binding EGF-like growth factor decreases apoptosis in intestinal epithelial cells in vitro. J Pedtr Surg. 2001;36:1130
  39. Xia G, Lara-Marquez M, Luquette MH, et al. Heparin-binding EGF-like growth factor decreases inducible nitric oxide synthase and nitric oxide production after intestinal ischemia/reperfusion injury. Antioxidants Redox Signaling. 2001;3:919
  40. Leach RE, Kilburn BA, Petkova A, et al. Diminished survival of human cytotrophoblast cells exposed to hypoxia/reoxygenation injury and associated reduction of heparin-binding epidermal growth factor-like growth factor. Am J Obstet Gynecol. 2008;198:471.e1
  41. Pan B, Sengoku K, Goishi K, et al. The soluble and membrane-anchored forms of heparin-binding epidermal growth factor-like growth factor appear to play opposing roles in the survival and apoptosis of human luteinized granulosa cells. Mol Hum Reprod. 2002;8:734

PII: S0022-4804(10)00674-8

doi: 10.1016/j.jss.2010.07.058

Journal of Surgical Research
Volume 172, Issue 1 , Pages 165-176 , January 2012

Article Tools

* Image Usage & Resolution