Journal of Surgical Research
Volume 164, Issue 1 , Pages e125-e129 , November 2010

The Effects of BleedArrest, Celox, and TraumaDex on Hemorrhage Control in a Porcine Model

  • Brian Gegel, M.S.N.

      Affiliations

    • Assistant Program Director, Phase II Site, US Army Graduate Program in Anesthesia, Brooke Army Medical Center, Fort Sam, Houston, Texas
  • ,
  • James Burgert, M.S.N.A.

      Affiliations

    • Adjunct Clinical Faculty, Brooke Army Medical Center, Fort Sam, Houston, Texas
  • ,
  • Brian Cooley, B.S.N.

      Affiliations

    • Graduate Student, US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas
  • ,
  • Jacob MacGregor, B.S.N.

      Affiliations

    • Graduate Student, US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas
  • ,
  • Jules Myers, B.S.N.

      Affiliations

    • Graduate Student, US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas
  • ,
  • Sean Calder, B.S.N.

      Affiliations

    • Graduate Student, US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas
  • ,
  • Ralph Luellen, BSN

      Affiliations

    • Graduate Student, US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas
  • ,
  • Michael Loughren, Ph.D.

      Affiliations

    • Faculty, US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas
  • ,
  • Don Johnson, Ph.D.

      Affiliations

    • Faculty, US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Department of the Army, Academy of Health Sciences, 3490 Forage Road, Fort Sam Houston, TX, 78234-6130.

Received 20 May 2010

References 

  1. Sauaia A, Moore FA, Moore EE, et al. Epidemiology of trauma deaths: A reassessment. J Trauma. 1995;38:185
  2. Champion HR, Bellamy RF, Roberts CP, Leppaniemi A. A profile of combat injury. J Trauma. 2003;54(5 Suppl):S13
  3. Asensio JA, Petrone P, O’Shanahan G, et al. Managing exsanguination: What we know about damage control/bailout is not enough. Proc (Bayl Univ Med Cent). 2003;16:294
  4. Asensio JA, Petrone P, Roldan G, et al. Analysis of 185 iliac vessel injuries: Risk factors and predictors of outcome. Arch Surg. 2003;138:1187;discussion 1193
  5. Bellamy RF. The causes of death in conventional land warfare: Implications for combat casualty care research. Mil Med. 1984;149:55
  6. Gofrit ON, Leibovici D, Shapira SC, et al. The trimodal death distribution of trauma victims: Military experience from the Lebanon War. Mil Med. 1997;162:24
  7. Hoyt DB, Bulger EM, Knudson MM, et al. Death in the operating room: An analysis of a multi-center experience. J Trauma. 1994;37:426
  8. Mabry RL, Holcomb JB, Baker AM, et al. United States Army Rangers in Somalia: An analysis of combat casualties on an urban battlefield. J Trauma. 2000;49:515;discussion 528
  9. Sauaia A, Moore FA, Moore EE, et al. Early predictors of postinjury multiple organ failure. Arch Surg. 1994;129:39
  10. Cosgriff N, Moore EE, Sauaia A, et al. Predicting life-threatening coagulopathy in the massively transfused trauma patient: Hypothermia and acidoses revisited. J Trauma. 1997;42:857;discussion 861
  11. Heckbert SR, Vedder NB, Hoffman W, et al. Outcome after hemorrhagic shock in trauma patients. J Trauma. 1998;45:545
  12. Santry HP, Alam HB. Fluid resuscitation: Past, present, and the future. Shock. 2010;33:229
  13. Scope A, Farkash U, Lynn M, et al. Mortality epidemiology in low-intensity warfare: Israel Defense Forces’ experience. Injury. 2001;32:1
  14. Zajtchuk R, Sullivan GR. Battlefield trauma care: Focus on advanced technology. Mil Med. 1995;160:1
  15. Ward KR, Tiba MH, Holbert WH, et al. Comparison of a new hemostatic agent to current combat hemostatic agents in a swine model of lethal extremity arterial hemorrhage. J Trauma. 2007;63:276;discussion 283
  16. Pusateri AE, Delgado AV, Dick EJ, et al. Application of a granular mineral-based hemostatic agent (QuikClot) to reduce blood loss after grade V liver injury in swine. J Trauma. 2004;57:555;discussion 562
  17. Jewelewicz DD, Cohn SM, Crookes BA, et al. Modified rapid deployment hemostat bandage reduces blood loss and mortality in coagulopathic pigs with severe liver injury. J Trauma. 2003;55:275;discussion 280
  18. Bishoff JT, Cornum RL, Perahia B, et al. Laparoscopic heminephrectomy using a new fibrin sealant powder. Urology. 2003;62:1139
  19. Pusateri AE, Modrow HE, Harris RA, et al. Advanced hemostatic dressing development program: Animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in swine. J Trauma. 2003;55:518
  20. Sondeen JL, Pusateri AE, Coppes VG, et al. Comparison of 10 different hemostatic dressings in an aortic injury. J Trauma. 2003;54:280
  21. Pusateri AE, McCarthy SJ, Gregory KW, et al. Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine. J Trauma. 2003;54:177
  22. King DR, Cohn SM, Proctor KG. Modified rapid deployment hemostat bandage terminates bleeding in coagulopathic patients with severe visceral injuries. J Trauma. 2004;57:756
  23. Kheirabadi BS, Acheson EM, Deguzman R, et al. Hemostatic efficacy of two advanced dressings in an aortic hemorrhage model in swine. J Trauma. 2005;59:25;discussion 34
  24. Rothwell SW, Reid TJ, Dorsey J, et al. A salmon thrombin-fibrin bandage controls arterial bleeding in a swine aortotomy model. J Trauma. 2005;59:143
  25. Jackson MR, Friedman SA, Carter AJ, et al. Hemostatic efficacy of a fibrin sealant-based topical agent in a femoral artery injury model: A randomized, blinded, placebo-controlled study. J Vasc Surg. 1997;26:274
  26. Alam HB, Uy GB, Miller D, et al. Comparative analysis of hemostatic agents in a swine model of lethal groin injury. J Trauma. 2003;54:1077
  27. Alam HB, Chen Z, Jaskille A, et al. Application of a zeolite hemostatic agent achieves 100% survival in a lethal model of complex groin injury in swine. J Trauma. 2004;56:974
  28. Acheson EM, Kheirabadi BS, Deguzman R, et al. Comparison of hemorrhage control agents applied to lethal extremity arterial hemorrhages in swine. J Trauma. 2005;59:865;discussion 874
  29. Arnaud F, Tomori T, Saito R, et al. Comparative efficacy of granular and bagged formulations of the hemostatic agent QuikClot. J Trauma. 2007;63:775
  30. Ahuja N, Ostomel TA, Rhee P, et al. Testing of modified zeolite hemostatic dressings in a large animal model of lethal groin injury. J Trauma. 2006;61:1312
  31. Kozen BG, Kircher SJ, Henao J, et al. An alternative hemostatic dressing: Comparison of CELOX, HemCon, and QuikClot. Acad Emerg Med. 2008;15:74
  32. Wedmore I, McManus JG, Pusateri AE, et al. A special report on the chitosan-based hemostatic dressing: Experience in current combat operations. J Trauma. 2006;60:655
  33. Kheirabadi BS, Scherer MR, Estep JS, et al. Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine. J Trauma. 2009;67:450;discussion 459
  34. Kheirabadi BS, Edens JW, Terrazas IB, et al. Comparison of new hemostatic granules/powders with currently deployed hemostatic products in a lethal model of extremity arterial hemorrhage in swine. J Trauma. 2009;66:316;discussion 327
  35. Kues AB. The physical stature and bmi values of US Army personnel in 1988. J Biosoc Sci. 2008;40:481
  36. Pusateri AE, Holcomb JB, Kheirabadi BS, et al. Making sense of the preclinical literature on advanced hemostatic products. J Trauma. 2006;60:674
  37. Alam HB, Burris D, DaCorta JA, et al. Hemorrhage control in the battlefield: Role of new hemostatic agents. Mil Med. 2005;170:63

PII: S0022-4804(10)00676-1

doi: 10.1016/j.jss.2010.07.060

Journal of Surgical Research
Volume 164, Issue 1 , Pages e125-e129 , November 2010