Journal of Surgical Research
Volume 164, Issue 2 , Pages e221-e228 , December 2010

Development and Analysis of a Collagen-Based Hemostatic Adhesive

  • Seung Hyuk Baik, M.D., Ph.D.

      Affiliations

    • Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Korea
    • Program of Nano Science and Technology, Graduate School, Yonsei University, Seoul, Korea
    • Department of Surgery, Severance Hospital, Yonsei University, Seoul, Korea
  • ,
  • Jae Hyung Kim, M.S.

      Affiliations

    • Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Korea
    • Program of Nano Science and Technology, Graduate School, Yonsei University, Seoul, Korea
  • ,
  • Hyun Hee Cho, M.S.

      Affiliations

    • Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Korea
    • Program of Nano Science and Technology, Graduate School, Yonsei University, Seoul, Korea
  • ,
  • Si-Nae Park, Ph.D

      Affiliations

    • Dalim-Tissen Co., Ltd, Seoul, Korea
  • ,
  • Yu Seun Kim, M.D., Ph.D.

      Affiliations

    • Program of Nano Science and Technology, Graduate School, Yonsei University, Seoul, Korea
    • Department of Surgery, Severance Hospital, Yonsei University, Seoul, Korea
  • ,
  • Hwal Suh, D.D.S, Ph.D.

      Affiliations

    • Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Korea
    • Program of Nano Science and Technology, Graduate School, Yonsei University, Seoul, Korea
    • Department of Medical Engineering, Research Center for Nano Medical engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    • Corresponding Author InformationTo whom correspondence and reprint requests should be addressed at Laboratory of Tissue Regenerative Medicine, Department of Medical Engineering, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-ku, 120-752, Seoul, Korea.

Received 10 May 2010

References 

  1. Patel MJ, Garg R, Rice DH. Benefits of fibrin sealants in parotidectomy: Is underflap suction drainage necessary?. Laryngoscope. 2006;116:1708
  2. Matthews TW, Briant TD. The use of fibrin tissue glue in thyroid surgery: Resource utilization implications. J Otolaryngol. 1991;20:276
  3. Marchac D, Greensmith AL. Early postoperative efficacy of fibrin glue in face lift: A prospective randomized trial. Plast Reconstr Surg. 2005;115:911
  4. Hino M, Ishiko O, Honda KI, et al. Transmission of symptomatic parvovirus B19 infection by fibrin sealant used during surgery. Br J Haematol. 2000;108:194
  5. Horowitz B, Busch M. Estimation of the pathogen safety of manufactured human plasma products: Application to fibrin sealants and to thrombin. Transfusion. 2008;48:1739
  6. Oswald AM, Joly LM, Gury C, et al. Fatal intra-operative anaphylaxis related to aprotinin after local application of fibrin glue. Anesthesiology. 2003;99:762
  7. Busuttil RW. A comparison of antifibrinolytic agents used in hemostatic fibrin sealants. J Am Coll Surg. 2003;197:1021
  8. Spotnitz WD, Burks S. Hemostats, sealants, and adhesives: Components of the surgical toolbox. Transfusion. 2008;48:1502
  9. Package Insert. Coseal, Baxter. March, 2006.
  10. Package Insert, Duraseal, Covidien. 2005.
  11. Furst W, Banerjee A. Release of glutaraldehyde from an albumin-glutaraldehyde tissue adhesive causes significant in vitro and in vivo toxicity. Ann Thorac Surg. 2005;79:1522
  12. Miller JM, Zoll DR, Brown EO. Clinical observation on use of an extruded collagen suture. Arch Surg. 1964;88:167
  13. Chvapil M, Kronenthal L, Van Winkle W. Medical and surgical applications of collagen. Int Rev Connect Tissue Res. 1973;6:1
  14. Cameron WJ. A new topical hemostatic agent in gynecologic surgery. Obstet Gynecol. 1978;51:118
  15. Doillon CJ, Whyne CF, Brandwein S, et al. Collagen-based wound dressings: Control of the pore structure and morphology. J Biomed Mater Res. 1986;20:1219
  16. Petter-Puchner AH, Walder N, Redl H, et al. Fibrin sealant (Tissucol) enhances tissue integration of condensed polytetrafluoroethylene meshes and reduces early adhesion formation in experimental intra-abdominal peritoneal on-lay mesh repair. J Surg Res. 2008;150:190
  17. Lin KL, Yang DY, Chu IM, et al. DuraSeal as a ligature in the anastomosis of rat sciatic nerve gap injury. J Surg Res. 2010;161:101
  18. Choi BH, Kim BY, Huh JY, et al. Microneural anastomosis using cyanoacrylate adhesives. Int J Oral Maxillofac Surg. 2004;33:777
  19. Barceló Santana HF, Hernández Medina R, et al. Evaluation of bond strength of metal brackets by a resin to ceramic surfaces. J Clin Dent. 2006;17:5
  20. Dias LL, Giovani AR, Silva Sousa YT, et al. Effect of eugenol-based endodontic sealer on the adhesion of intra-radicular posts cemented after different periods. J Appl Oral Sci. 2009;17:579
  21. Wilson S, Pell P, Donegan EA. HIV-1 transmission following the use of cryoprecipitated fibrinogen as gel/adhesive. Transfusion. 1991;31:51S
  22. Kawamura M, Sawafuji M, Watanabe M, et al. Frequency of transmission of human parvovirus B19 infection by fibrin sealant used during thoracic surgery. Ann Thorac Surg. 2002;73:1098
  23. Mangano DT, Tudor IC, Dietzel C. The risk associated with Aprotinin in cardiac surgery. N Engl J Med. 2006;354:353
  24. Alston TA. Aprotinin. Int Anesthesiol Clin. 2004;42:81
  25. Toshiya S, Zen’ichiro W, Tetuo I, et al. Aprotinin in major orthopedic surgery: A systematic review of randomized controlled trials. Anesth Analg. 2005;101:1602
  26. Mahdy A, Webster N. Perioperative systemic haemostatic agents. Br J Anaesth. 2004;93:842
  27. Longstaff C. Studies on the mechanisms of action of aprotinin and tranexamic acid as plasmin inhibitors and antifibrinolytic agents. Blood Coagul Fibrinolys. 1994;5:537
  28. Brown RS, Thwaites BK, Mongan PD. Tranexamic acid is effective in decreasing postoperative bleeding and transfusions in primary coronary artery bypass operations: A double-blind, randomized, placebo-controlled trial. Anesth Analg. 1997;85:963
  29. Casati V. About dosage schemes and safety of tranexamic acid in cardiac surgery. Anesthesiology. 2003;99:236
  30. Thiagarajamurthy S, Levine A, Dunning J. Does prophylactic tranexamic acid safely reduce bleeding without increasing thrombotic complications in patients undergoing cardiac surgery?. Interact Cardiovasc Thorac Surg. 2004;3:489
  31. Harley B, Beaupré L, Jones A, et al. The effect of epsilon aminocaproic acid on blood loss in patients who undergo primary total hip replacement: A pilot study. Can J Surg. 2002;45:185

PII: S0022-4804(10)00681-5

doi: 10.1016/j.jss.2010.08.004

Journal of Surgical Research
Volume 164, Issue 2 , Pages e221-e228 , December 2010