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Research Article| Volume 50, ISSUE 3, P228-233, March 1991

Intestinal diamine oxidase levels reflect ischemic injury

DOI:https://doi.org/10.1016/0022-4804(91)90183-M
Intestinal diamine oxidase levels reflect ischemic injury
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      Abstract

      Mucosal diamine oxidase (DAO) decreases during intestinal ischemia and may be a useful marker of intestinal ischemic injury. Tissue DAO activity and histologic changes were studied in intestinal segments taken from the midpoint of the small intestine before and 2, 4, and 24 hr after manipulation of the intestinal blood supply in 24 mongrel dogs. Intestinal DAO activity decreased significantly (17 ± 21% of control value) 24 hr after SMA ligation and was associated with abnormal histology (histology score 7.8 ± 2.9 at 24 hr vs 0.3 ± 0.5 at 0 hr). SMA occlusion for 2 hr resulted in a significant decrease in DAO activity (45 ± 36% of control value) 4 hr after manipulation which returned to normal at 24 hr, as did the histologic injury. Ligation of both the mesenteric arteries and veins resulted in a more rapid decrease in DAO activity. Decreased DAO activity correlated with the extent of histologic injury. Intestinal ischemia is associated with decreased intestinal DAO activity, which is influenced by the mechanism and duration of intestinal ischemia.
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      References

        • Kobayashi Y.
        • Kupelian J.
        • Maudsley D.V.
        Release of diamine oxidase by heparin in the rat.
        Biochem. Pharmacol. 1969; 18: 1585
        • Thompson J.S.
        • Burnett D.A.
        • Markin R.S.
        • Vaughan W.P.
        Intestinal diamine oxidase activity reflects intestinal involvement in Crohn's disease.
        Amer. J. Gastroenterol. 1988; 83: 756
        • Mennigen R.
        • Kusche J.
        • Erpenbach K.
        Adaptive response of the rat small bowel to 70% resection: Is the intestinal diamine oxidase involved in mucosal growth regulation?.
        Biogenic Amines. 1988; 5: 55
        • Wollin A.
        • Navert H.
        • Bounous G.
        Effect of intestinal ischemia on diamine oxidase activity in rat intestinal tissue and blood.
        Gastroenterology. 1981; 80: 349
        • Menningen R.
        • Gunther M.
        • Bönninghoff N.
        • Stahlknecht C.-D.
        • Kubitza I.
        • Kusche J.
        Diamine oxidase as a marker of intestinal integrity in acute appendicitis.
        Agents Actions. 1986; 18: 38
        • Ely M.J.
        • Speicher J.M.
        • Catravas G.N.
        • Snyder S.L.
        Radiation effects on diamine oxidase activities in intestine and plasma of the rat.
        Radiat. Res. 1985; 103: 158
        • Menningen R.
        • Kusche J.
        • Leisten L.
        • Erpenbach K.
        Diamine oxidase (DAO) activity and intestinal mucosa integrity: Influence of suture techniques.
        Agents Actions. 1987; 20: 277
        • Thompson J.S.
        • Vaughan W.P.
        • Forst C.F.
        • Jacobs D.L.
        • Weekly J.S.
        • Rikkers L.F.
        The effect of the route of nutrient delivery on gut structure and diamine oxidase levels.
        JPEN. 1987; 11: 28
        • Kusche J.
        • Lorenz W.
        • Stahlknecht C.-D.
        • et al.
        Intestinal diamine oxidase and histamine release in rabbit mesenteric ischemia.
        Gastroenterology. 1981; 80: 980
        • Kusche J.
        • Stahlknecht C.-D.
        • Lorenz W.
        • Reichert G.
        • Dietz W.
        Comparison of alterations in the histamine-diamine oxidase system during acute intestinal ischemia in pigs, dogs, and rabbits: Evidence for a uniform pathophysiological mechanism?.
        Agent Actions. 1979; 9: 49
        • Parks D.A.
        • Granger D.N.
        Contributions of ischemia and reperfusion to mucosal lesion formation.
        Amer. J. Physiol. 1986; 250: G749
        • Brown R.A.
        • Chiu C.J.
        • Scott H.J.
        • Gurd F.N.
        Ultrastructural changes in the canine ileal mucosal cell after mesenteric arterial occlusion.
        Arch. Surg. 1970; 101: 290
        • Williams L.F.
        Mesenteric ischemia.
        Surg. Clin. N. Amer. 1988; 68: 331
        • Luk G.D.
        • Bayliss T.M.
        • Baylin S.B.
        Diamine oxidase: A circulating marker for rat intestinal maturation and integrity.
        J. Clin. Invest. 1980; 66: 66
        • Kusche J.
        • Stahlknecht C.-D.
        • Lorenz W.
        • Reichert G.
        • Richter H.
        Diamine oxidase activity and histamine release in dogs following acute mesenteric artery occlusion.
        Agents Actions. 1977; 5: 81
        • Kusche J.
        • Richter H.
        • Schmidt J.
        • Hesterberg R.
        • Friedrich A.
        • Lorenz W.
        Diamine oxidase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia.
        Agents Actions. 1975; 5: 431
        • Robinson-White A.
        • Baylin S.B.
        • Olivecroma T.
        • Beaven M.A.
        Binding of diamine oxidase activity to rat and guinea pig microvascular endothelial cells.
        J. Clin. Invest. 1985; 76: 93
        • Bounous G.
        • Echave V.
        • Vobecky S.J.
        • Navert H.
        • Wollin A.
        Acute necrosis of the intestinal mucosa with high serum levels of diamine oxidase.
        Dig. Dis. Sci. 1984; 29: 872

      Article info

      Publication history

      Received: January 11, 1990

      Identification

      DOI: https://doi.org/10.1016/0022-4804(91)90183-M

      Copyright

      © 1991 Published by Elsevier Inc.

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