Surgeons around the world evaluate and treat problems on a daily basis which have
a common theme: ischemic tissue. Early studies have demonstrated that treatment with
stem cells or the growth factors they produce can protect ischemic tissue [
1
,
2
]. Investigators are now augmenting the effects of cell-based therapy to enhance protection
from ischemia [
3
,
4
,
5
].To read this article in full you will need to make a payment
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References
- Vascular endothelial growth factor improves myocardial functional recovery following ischemia/reperfusion injury.J Surg Res. 2008; 150: 286
- Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium.Regul Pept. 2004; 117: 3
- Cell-based therapy for ischemic heart disease: A clinical update.Ann Thorac Surg. 2009; 88: 1714
- TNF-Alpha preconditioning of human bone marrow mesenchymal stem cells does not improve stem cell acute myocardial protection after ischemia/reperfusion.Inflammation Research. 2007; 56: S168
- IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.Proc Natl Acad Sci USA. 2009; 106: 17499
- Vascular endothelial growth factor (VEGF165) plus basic fibroblast growth factor (bFGF) producing cells induce a mature and stable vascular network – a future therapy for ischemically challenged tissue.J Surg Res. 2010; (in press)
Article info
Publication history
Published online: June 17, 2010
Received:
May 14,
2010
Identification
Copyright
© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.