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Improving Cell-Based Treatment for Ischemic Tissue

      Surgeons around the world evaluate and treat problems on a daily basis which have a common theme: ischemic tissue. Early studies have demonstrated that treatment with stem cells or the growth factors they produce can protect ischemic tissue [
      • Guzman M.J.
      • Crisostomo P.R.
      • Wang M.
      • et al.
      Vascular endothelial growth factor improves myocardial functional recovery following ischemia/reperfusion injury.
      ,
      • Tang Y.L.
      • Zhao Q.
      • Zhang Y.C.
      • et al.
      Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium.
      ]. Investigators are now augmenting the effects of cell-based therapy to enhance protection from ischemia [
      • Herrmann J.L.
      • Abarbanell A.M.
      • Weil B.R.
      • et al.
      Cell-based therapy for ischemic heart disease: A clinical update.
      ,
      • Markel T.
      • Crisostomo P.
      • Lahm T.
      • et al.
      TNF-Alpha preconditioning of human bone marrow mesenchymal stem cells does not improve stem cell acute myocardial protection after ischemia/reperfusion.
      ,
      • Wang M.
      • Tan J.
      • Wang Y.
      • et al.
      IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.
      ].
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      References

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        • Crisostomo P.R.
        • Wang M.
        • et al.
        Vascular endothelial growth factor improves myocardial functional recovery following ischemia/reperfusion injury.
        J Surg Res. 2008; 150: 286
        • Tang Y.L.
        • Zhao Q.
        • Zhang Y.C.
        • et al.
        Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium.
        Regul Pept. 2004; 117: 3
        • Herrmann J.L.
        • Abarbanell A.M.
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        Cell-based therapy for ischemic heart disease: A clinical update.
        Ann Thorac Surg. 2009; 88: 1714
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        • et al.
        TNF-Alpha preconditioning of human bone marrow mesenchymal stem cells does not improve stem cell acute myocardial protection after ischemia/reperfusion.
        Inflammation Research. 2007; 56: S168
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        • Tan J.
        • Wang Y.
        • et al.
        IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.
        Proc Natl Acad Sci USA. 2009; 106: 17499
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        Vascular endothelial growth factor (VEGF165) plus basic fibroblast growth factor (bFGF) producing cells induce a mature and stable vascular network – a future therapy for ischemically challenged tissue.
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