Background
There are few studies that focus on the important organs injuries induced by total
hepatic ischemia and reperfusion (THIR), which is a key to save the lives of hepatic
surgery patients. We evaluated changes in the hydrogen sulphide production system
and injuries to the heart and kidney. The aim of this study was to assess whether
sodium hydrosulphide (NaHS) has protective effects against THIR injury.
Materials and Methods
Under anaesthesia of the Wistar rats, the hepatic artery, the portal vein, and the
inferior vena cava above and below the liver were clamped with nontraumatic arterial
clamps. Hepatic reperfusion was achieved by removing the clamps.
Results
Hydrogen sulphide production system was down-regulated after THIR, which caused severe
damage to the heart and kidney, apart from the liver. In treated animals, CK-MB and
LDH were lower by 26.9% and 14.2% (P < 0.05), respectively. The kidney showed similar change. Hematoxylin and eosin staining
demonstrated fewer injuries in NaHS treated animals. The results indicated that the
damage was abolished by exogenous NaHS.
Conclusions
The observed protection of exogenous NaHS is associated with reduced myocardial and
renal inflammation and oxidative potential after THIR. The current results suggest
that hydrogen sulphide is protective during the evolution of THIR and that either
direct hydrogen sulphide administration or the modulation of endogenous production
may be of clinical importance.
Key Words
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Article info
Publication history
Published online: September 09, 2010
Received:
May 14,
2010
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
