Tacrolimus Attenuates Myocardium Damage to the Total Hepatic Ischemia-Reperfusion Via Regulation of the Mitochondrial Function

  • Yawei Chen
    First Department of Comprehensive Surgery, South Building, PLA General Hospital of China, Beijing, China
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  • Xiaohua Xie
    To whom correspondence and reprint requests should be addressed at First Department of Comprehensive Surgery, South Building, PLA General Hospital of China, 28th Rd, Haidian Dis, Beijing 100853, China.
    First Department of Comprehensive Surgery, South Building, PLA General Hospital of China, Beijing, China
    Search for articles by this author
Published:November 15, 2010DOI:


      Ischemia and reperfusion injury to the liver remains an important clinical problem during liver transplantation and the protection of myocardial function is critical for patients suffering liver transplantation. In the present study, we evaluated the effect of tacrolimus on injured myocardium and mitochondria after total hepatic ischemia-reperfusion (THIR).


      We utilized the THIR model to mimic the liver transplantation and evaluate the myocardial injury after THIR. Male Wistar rats were divided into four groups: control (sham operated); THIR; THIR+tacrolimus (intraperitoneally, 0.1 mg/kg), and tacrolimus alone group.


      THIR indeed damaged the myocardial and mitochondrial function, including increasing the level of MB isoenzyme of creatine kinase (CK-MB) and lactate dehydrogenase (LDH), decreasing mitochondrial transmembrane potential (MTP), mitochondrial respiratory and phosphorylating activities (P < 0.05). After administration of tacrolimus, myocardial injuries were significantly attenuated (P < 0.05).


      THIR injury was associated with myocardial injury, perhaps resulting from mitochondrial function alterations. The inhibition of calcineurin and the improvement of mitochondrial respiration and antioxidant capacity maybe contributed to the protection of myocardial mitochondria function after THIR.

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