Background
Ischemia and reperfusion injury to the liver remains an important clinical problem
during liver transplantation and the protection of myocardial function is critical
for patients suffering liver transplantation. In the present study, we evaluated the
effect of tacrolimus on injured myocardium and mitochondria after total hepatic ischemia-reperfusion
(THIR).
Methods
We utilized the THIR model to mimic the liver transplantation and evaluate the myocardial
injury after THIR. Male Wistar rats were divided into four groups: control (sham operated);
THIR; THIR+tacrolimus (intraperitoneally, 0.1 mg/kg), and tacrolimus alone group.
Results
THIR indeed damaged the myocardial and mitochondrial function, including increasing
the level of MB isoenzyme of creatine kinase (CK-MB) and lactate dehydrogenase (LDH),
decreasing mitochondrial transmembrane potential (MTP), mitochondrial respiratory
and phosphorylating activities (P < 0.05). After administration of tacrolimus, myocardial injuries were significantly
attenuated (P < 0.05).
Conclusion
THIR injury was associated with myocardial injury, perhaps resulting from mitochondrial
function alterations. The inhibition of calcineurin and the improvement of mitochondrial
respiration and antioxidant capacity maybe contributed to the protection of myocardial
mitochondria function after THIR.
Key Words
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Article info
Publication history
Published online: November 15, 2010
Accepted:
October 15,
2010
Received:
July 21,
2010
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
