Abstract
Background
We tested the hypothesis that racial differences that exist in the distribution of
ABO blood type would partially explain the racial disparity in overall survival seen
in colorectal cancer.
Methods
retrospective analysis of the cancer registry of a university hospital for patients
treated for colorectal cancer between 1996 and 2008. Demographic, tumor-specific,
and treatment-specific variables were abstracted. We also obtained ABO blood group
data. The primary end point was overall survival. We divided patients into two groups
based on where they underwent surgery: the University of Arkansas for Medical Sciences
(UAMS) or outside facilities.
Results
Of 833 patients, 182 (21.8%) were black. There was no difference in overall survival
between blacks and whites for the entire group (P = 0.61). There was a statistically significant difference in overall survival between
patients at the UAMS and outside facilities (P < 0.0001). For the outside facilities group, there was a statistically significant
difference in overall survival between blacks and whites (hazard ratio, CI: 1.48 [1.06–2.00];
P = 0.012); no race difference existed for the UAMS group. The ABO blood group had
no effect on overall survival. On stage-stratified univariate and multivariate analyses,
chemotherapy and surgery were the only statistically significant determinants of survival.
Conclusions
In this study, racial differences in ABO blood group distribution had no effect on
overall survival.
Keywords
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Article info
Publication history
Published online: December 26, 2012
Accepted:
November 19,
2012
Received in revised form:
October 27,
2012
Received:
September 1,
2012
Footnotes
The authors retain the right to provide a copy of the final manuscript to the NIH upon acceptance for journal publication, for public archiving in PubMed Central as soon as possible but no later than 12 months after publication by the journal.
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
