Proinflammatory states are widely implicated in both acute and chronic disease processes.
Severe acute systemic inflammation is at least partially responsible for shock and
acute lung injury, and therapeutic options to curb the proinflammatory responses are
limited. Sustained release of proinflammatory mediators by macrophages and other leukocyte
subtypes is the hallmark of autoimmune illnesses. In addition to nonspecific immunosuppressants,
targeted therapies to reduce inflammation via inhibition of cytokine release are available
for some of these illnesses, including Crohn disease and rheumatoid arthritis. However,
the subsequent risk of infection with these medications is significant, which limits
their clinical use.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Surgical ResearchAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Anti-inflammatory effects of linalool in RAW 264.7 macrophages and lipopolysaccharide-induced lung injury model.J Surg Res. 2013; 180: e47
- Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.N Engl J Med. 1998; 338: 347
- Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature.Crit Care Med. 1995; 23: 1430
- Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review.JAMA. 2009; 301: 2362
Article info
Publication history
Published online: March 04, 2013
Accepted:
February 7,
2013
Received in revised form:
January 29,
2013
Received:
January 29,
2013
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Anti-inflammatory effects of linalool in RAW 264.7 macrophages and lipopolysaccharide-induced lung injury modelJournal of Surgical ResearchVol. 180Issue 1
- PreviewInflammation, characterized by redness, swelling, pain and a sensation of heat, is one of the body’s self-defense systems. Although the inflammation response has an important role in host survival, it also leads to chronic inflammatory diseases. Linalool is a natural compound of the essential oils in several aromatic plants species. It possesses anti-inflammatory, antinociceptive, and other bioactive properties. In the present study, we investigated the protective effects of linalool on inflammation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and an LPS-induced in vivo lung injury model.
- Full-Text
- Preview
