Abstract
Background
Lobular carcinoma of the male breast is rare. We sought to investigate the clinical
characteristics, treatment, and outcomes of men and women with lobular breast cancer,
using a population-based database.
Methods
We reviewed the Surveillance, Epidemiology, and End Results database 1988–2008 and
identified patients with a lobular breast cancer diagnosis (invasive lobular carcinoma
[ILC] and lobular carcinoma in situ [LCIS]) using the “International Classification of Diseases for Oncology, Third Edition”
codes. Bivariate analyses compared the male and female patients on demographics, clinical
characteristics, and treatment modalities. Multivariate logistic regression analysis
determined the risk-adjusted likelihood of receiving treatment. Survival analysis
was done and hazard ratios were obtained using Cox proportional models.
Results
Overall, 133,339 patients were identified, including 133,168 women (99.9%) and 171
men (0.1%). Most had ILC (82.08%). The median age was 66 ± 20 y for the men and 61
± 21 y for the women. The men with ILC were more likely to have poorly differentiated
tumors (26.45% versus 15.61%; P < 0.001) and stage IV disease (9.03% versus 4.18%; P = 0.005) than were the women. The cancer-specific 5-year survival rates for ILC were
82.9% for the men and 91.9% for the women. Adjusted survival was better for patients
with ILC receiving surgery plus radiotherapy than patients receiving neither (hazard
ratio 0.52, 95% confidence interval 0.49–0.56). Women with ILC had a 55% increased
odds of receiving surgery plus radiotherapy compared with men (odds ratio 1.55, 95%
confidence interval 1.08–2.22).
Conclusions
ILC presents at a higher grade and stage in men. The difference in disease characteristics
and survival rates suggests that the treatment of men with lobular breast cancer should
be adjusted to improve their outcomes.
Keywords
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Article info
Publication history
Published online: June 05, 2013
Accepted:
May 9,
2013
Received in revised form:
May 3,
2013
Received:
January 5,
2013
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
