Abstract
Acute respiratory distress syndrome (ARDS) is a common critical pulmonary complication
after esophagectomy and other thoracic surgeries (e.g., lung transplantation, pulmonary
thromboendarterectomy). Direct pulmonary ischemia–reperfusion injury (PIRI) is known
to play the main role in induction of ARDS in these cases. Large animal models are
an appropriate choice for ARDS as well as PIRI study because of their physiological
and anatomic similarities to the human body. With regard to large animal models, we
reviewed different methods of inducing in situ direct PIRI and the commonly applied methods for diagnosing and monitoring ARDS or
PIRI in an experimental research setting.
Keywords
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Article info
Publication history
Published online: February 26, 2014
Accepted:
February 20,
2014
Received in revised form:
January 17,
2014
Received:
October 21,
2013
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
