Highlights
- •PTC with ≥ 50% PDC would be more aggressive disease than PTC with < 50% PDC.
- •PTC with ≥ 50% PDC shows higher NLR PTC with < 50% PDC.
- •NLR represents the aggressiveness of PTC harboring PDC.
Abstract
Introduction
Diagnosis of poorly differentiated thyroid cancer (PDTC) requires ≥ 50% of poorly
differentiated components (PDC) in Japan. However, the optimal cutoff percentage of
PDC for PDTC diagnosis remains controversial. Although high neutrophil-to-lymphocyte
ratio (NLR) correlates with the aggressiveness of papillary thyroid cancer (PTC),
whether NLR is associated with the proportion of PDC in PTC remains unstudied.
Materials and methods
Patients with the pure PTC (n = 664), PTC with < 50% PDC (n = 19), or PTC with ≥ 50% PDC (n = 26) who underwent surgery were retrospectively analyzed. Twelve-year disease-specific
survival and preoperative NLR were compared among these groups.
Results
Twenty seven patients died from thyroid cancer. The PTC with ≥ 50% PDC group (80.7%)
showed significantly worse 12-year disease-specific survival than the pure PTC group
(97.2%) (P < 0.001); however, the < 50% PDC group (94.7%) did not (P = 0.91). The PTC with ≥ 50% PDC group had a significantly higher NLR than the pure
PTC (P < 0.001) and the PTC with < 50% PDC groups (P < 0.001), whereas there was no significant difference in the NLR between the pure
PTC and the PTC with < 50% PDC groups (P = 0.48).
Conclusions
PTC with ≥ 50% PDC is more aggressive than either pure PTC or PTC with < 50% PDC,
and NLR potentially reflects the PDC proportion. These results support the validity
of 50% PDC as a cut-off for PDTC diagnosis and indicate the utility of NLR as a biomarker
for PDC proportion.
Keywords
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Article info
Publication history
Published online: March 01, 2023
Accepted:
January 30,
2023
Received in revised form:
January 5,
2023
Received:
August 22,
2022
Identification
Copyright
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