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Abstract
Proximal gastric vagotomy (PGV) is a first-choice approach for the surgical treatment
of duodenal peptic ulcer. However, a high percentage of recidivism takes place after
this surgical strategy. To study the possible involvement of gastrin in ulcer recidivism,
serum gastrin levels and gastrin receptors in gastric mucosa were determined at several
times after PGV in rats. Gastrin concentration was determined using a commercial radioimmunoassay
kit and gastrin receptors were analyzed in oxyntic mucosa membrane preparations using125I-labeled 15-Leu–gastrin-17 as label. Our results show a significant, time-dependent
increase in serum gastrin concentration, reaching highest values at 12 weeks after
PGV. Similarly, a significant increase in the number of gastrin receptors (Bmax) and in the dissociation constant (Kd) occurred from 1 to 12 weeks post-PGV. Since gastrin exerts a positive feedback effect
on its receptors, the PGV-dependent increase in serum gastrin concentration explains
the up-regulation of the gastrin receptors in the rat oxyntic mucosa. Furthermore,
an increase in the number of gastrin receptors after vagotomy may be at least partially
responsible for the recidivism in duodenal peptic ulcers after this surgical approach.
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Copyright
© 1997 Academic Press. Published by Elsevier Inc. All rights reserved.
