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  • Transplantation/Immunology

    Cardiotrophin-1 reduces ischemia/reperfusion injury during liver transplant

    Journal of Surgical Research
    Vol. 181Issue 2e83–e91Published online: August 10, 2012
    • Patricia Aguilar-Melero
    • Antonio Luque
    • María M. Machuca
    • María P. Pérez de Obanos
    • Rocío Navarrete
    • Inés C. Rodríguez-García
    • and others
    Cited in Scopus: 25
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      Orthotopic liver transplantation (OLT) is currently the elective treatment for advanced liver cirrhosis and acute liver failure. Ischemia/reperfusion damage may jeopardize graft function during the postoperative period. Cardiotrophin-1 (CT-1) has demonstrated cytoprotective properties in different experimental models of liver injury. There is no evidence to demonstrate its potential use in the prevention of the ischemia/reperfusion injury that occurs during OLT. The present study is the first report to show that the administration of CT-1 to donors would benefit the outcome of OLT.
      Cardiotrophin-1 reduces ischemia/reperfusion injury during liver transplant
    • Gastrointestinal

      Impact of Age on Liver Regeneration Response to Injury After Partial Hepatectomy in a Rat Model

      Journal of Surgical Research
      Vol. 175Issue 1e1–e9Published online: December 16, 2011
      • Juan Manuel Sánchez-Hidalgo
      • Álvaro Naranjo
      • Rubén Ciria
      • Isidora Ranchal
      • Patricia Aguilar-Melero
      • Gustavo Ferrín
      • and others
      Cited in Scopus: 20
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        Liver resection is a feasible treatment for multiple liver diseases. There is no evidence about the impact of age on liver regeneration.
        Impact of Age on Liver Regeneration Response to Injury After Partial Hepatectomy in a Rat Model
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