Acute appendicitis remains the most common abdominal surgical emergency [1]. In the United States alone, approximately 280,000 appendectomies are performed each year [2], and approximately 11 of every 10,000 Americans will develop acute appendicitis in their lifetime [3]. Despite the frequency with which this disease occurs, the exact etiology in most cases remains elusive. In monitoring changes in the epidemiology of acute appendicitis around the world, there have been many theories, which have raised more questions than answers.