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    Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

    Journal of Surgical Research
    Vol. 171Issue 1e97–e106Published online: April 13, 2011
    • Ming-Chang Kao
    • Woan-Ching Jan
    • Pei-Shan Tsai
    • Tao-Yeuan Wang
    • Chun-Jen Huang
    Cited in Scopus: 36
    Online Only
      Lower limb ischemia-reperfusion (I/R) elicits oxidative stress and causes inflammation in lung tissues that may lead to lung injury. Magnesium sulfate (MgSO4) possesses potent anti-oxidation and anti-inflammation capacity. We sought to elucidate whether MgSO4 could mitigate I/R-induced lung injury. As MgSO4 is an L-type calcium channel inhibitor, the role of the L-type calcium channels was elucidated.
      Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

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