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E-Only Articles
Platonin Inhibits Endotoxin-Induced MAPK and AP-1 Up-Regulation
We previously have shown that platonin, a potent antioxidant, significantly attenuated inflammatory molecules up-regulation in RAW264.7 cells, a murine macrophage-like cell line. Inflammatory molecules expression is under the regulation of activator protein-1 (AP-1), a crucial transcription factor and a heterodimeric protein that composes of proteins from c-Jun and c-Fos families. AP-1 expression is regulated by mitogen-activated protein kinases (MAPKs). We sought to elucidate the effects of platonin on MAPKs and AP-1 up-regulation in activated RAW264.7 cells.
