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  • Shock/Sepsis/Trauma/Critical Care

    Pretreatment of Rho Kinase Inhibitor Inhibits Systemic Inflammation and Prevents Endotoxin-Induced Acute Lung Injury in Mice

    Journal of Surgical Research
    Vol. 171Issue 2e209–e214Published online: September 5, 2011
    • Ren Yu Ding
    • Dong Mei Zhao
    • Zhi Dan Zhang
    • Ren Xuan Guo
    • Xiao Chun Ma
    Cited in Scopus: 28
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      Systemic inflammatory mediators play an important role in the development of sepsis. In this study, we analyzed the role of Rho kinase in the activation of immune response and acute lung injury in a mouse model of sepsis.
      Pretreatment of Rho Kinase Inhibitor Inhibits Systemic Inflammation and Prevents Endotoxin-Induced Acute Lung Injury in Mice
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