Comparison of “Open Lung” Modes with Low Tidal Volumes in a Porcine Lung Injury ModelVentilator strategies that maintain an “open lung” have shown promise in treating hypoxemic patients. We compared three “open lung” strategies with standard of care low tidal volume ventilation and hypothesized that each would diminish physiologic and histopathologic evidence of ventilator induced lung injury (VILI).
Titration of Mean Airway Pressure and FiO2 During High Frequency Oscillatory Ventilation in a Porcine Model of Acute Lung InjuryHigh frequency oscillatory ventilation (HFOV) is frequently utilized for patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, precise criteria to titrate mean airway pressure (mPaw) and FiO2 as the patient’s condition improves are lacking. We hypothesized that reducing mPaw and FiO2 too quickly after reaching target arterial oxygen saturation levels would promote ventilator induced lung injury (VILI).