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  • Commentary

    Selective occlusion of the portal vein while maintaining hepatic artery blood flow during partial hepatectomy: a new method for preventing ischemia-reperfusion injury?

    Journal of Surgical Research
    Vol. 185Issue 1e45–e48Published online: September 27, 2012
    • Ansgar Brüning
    • Ioannis Mylonas
    Cited in Scopus: 3
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      The liver is an essential multifunctional organ with diverse vital functions in nutrient metabolism, blood and bile formation, detoxification, and hormone production. Liver function can be impaired by drug and alcohol abuse, food and environmental toxins, metabolic disorders, viral infections, and congenital defects. Primary liver cancer and liver metastases, primarily from colorectal cancer, can also cause life-threatening damage to the liver [1]. Depending on comorbidities, tumor size, and the segmental distribution of tumors in the liver, the techniques of ablation, resection, or liver transplantation remain the most important and successful treatment modalities for primary and secondary liver cancer [2,3].
    • Commentary

      Cbfa1/Runx2-transduced adult adipose stem cells on biodegradable scaffolds for segmental bone defect repair

      Journal of Surgical Research
      Vol. 185Issue 1e67–e68Published online: July 9, 2012
      • Ansgar Brüning
      • Ioannis Mylonas
      Cited in Scopus: 0
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        Segmental bone defects can be caused by various pathologic conditions such as trauma, nonunion fractures, cancer treatment–related surgery for osteosarcomas and bone metastases, bacterial infections, inflammation, or congenital defects [1,2]. Depending on the amount and characteristics of the segmental bone loss, repair and regeneration can pose a clinical challenge for surgeons. In cases where autogenous or allogeneic bone grafting is not possible due to patient characteristics or the size or availability of the required bone transplant, modern techniques of skeletal tissue engineering can provide vital support for successful healing and reconstruction [3].
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