Experimental study on the effect of controlled hypotension levels on rabbit CA1 neuronsThe present study investigated the effect of controlled hypotension (CH) levels regulated by nitroprusside on hippocampal CA1 neurons.
IL-6, TNF-α, and iNOS is associated with decreased colonic contraction in rats with multiple organ dysfunction syndromeGastrointestinal stasis is frequently accompanied by multiple organ dysfunction syndrome (MODS), which may lead to gastrointestinal smooth muscle dysfunction. The aim of this study is to investigate whether MODS initiates an inflammatory response and produces IL-6, TNF-α, and iNOS cytokines, as well as to determine whether these cytokines give rise to gastrointestinal smooth muscle dysfunction.
Impact of Age on Liver Regeneration Response to Injury After Partial Hepatectomy in a Rat ModelLiver resection is a feasible treatment for multiple liver diseases. There is no evidence about the impact of age on liver regeneration.
Peptide Inhibitors of MK2 Show Promise for Inhibition of Abdominal AdhesionsAbdominal adhesions are a common side effect of surgical procedures with complications including infertility, chronic pain, and bowel obstruction, which may lead to the need for surgical lyses of the adhesions. Mitogen-activated protein kinase-activated protein kinase 2 (MK2) has been implicated in several diseases, involving inflammation and fibrosis. Thus, the development of a cell-penetrating peptide (CPP) that modulates MK2 activity may confer therapeutic benefit after abdominal surgery in general and more specifically after bowel anastomosis.
Split-Liver Procedure and Inflammatory Response: Improvement by Pharmacological PreconditioningFinal outcome of split-liver (SL) transplantation is impaired due to an increased rate of vascular complications and primary non-function. Herein, we hypothesized that an in situ split-liver procedure induces an inflammatory response and a deterioration of graft quality. We further studied whether graft quality can be improved by pharmacologic preconditioning.
TAKEDA-143242 Increased Survival Via Reduced Cytokines in Porcine PeritonitisTAKEDA-143242 (TAK-242) is a small molecule shown to inhibit lipopolysaccharide-induced intracellular signaling and inflammation. In vitro studies demonstrated that TAK-242 can prevent release of TNF-α, IL-1β, and IL-6 from activated macrophages of several species, including pigs. This study tested the hypothesis that TAK-242 would protect pigs from lethal gram-negative peritonitis via an anti-cytokine mechanism. A validated model of porcine gram-negative peritonitis, which employs chronically inplantated cardiac transducers and aortic and pulmonary artery catheters, was used.