Small Intestinal Submucosa Seeded with Intestinal Smooth Muscle Cells in a Rodent Jejunal Interposition ModelSmall intestinal submucosa (SIS) is a porcine-derived, acellular, collagen-based matrix that has been tested without seeded smooth muscle cells (SMCs) for intestinal tissue engineering. We examined the expression patterns of contractile proteins of SIS with SMCs implanted in an in vivo rodent model.
Effects of Progesterone on Intestinal Inflammatory Response and Mucosa Structure Alterations Following SAH in Male RatsSubarachnoid hemorrhage (SAH) can induce a persistent inflammatory response, histopathologic changes in the gut. This study investigated whether progesterone administration modulates intestinal proinflammatory cytokine expression and structure alternations following SAH in male rats.
Lymphocyte Depletion and Repopulation in Peripheral Blood and Small Intestine of Cynomolgus Monkeys After Alemtuzumab TreatmentAlemtuzumab has been used as an induction agent in organ transplantation over 10 years, but the effect of alemtuzumab on lymphocytes in small intestine was not clear. We investigate lymphocyte depletion and repopulation phenomena both in peripheral blood and small intestine of cynomolgus monkeys, to assess the model using in preclinical transplantation.
Protection by Pyruvate Infusion in a Rat Model of Severe Intestinal Ischemia-Reperfusion InjurySeveral lines of evidence suggest a strong protective potential of pyruvate against ischemia-reperfusion injury. Here, we studied the effect of pyruvate infusion on injury of the small intestine and on systemic parameters in a rat model of severe mesenteric ischemia-reperfusion injury.
Proteomics of Ischemia/Reperfusion Injury in Rat Intestine With and Without Ischemic PostconditioningIntestinal ischemia/reperfusion (I/R) injury is a critical condition associated with high morbidity and mortality. Our previous study showed that ischemic postconditioning (IPo) protects the intestinal mucosa from I/R injury. However, the precise molecular mechanisms of this event remain poorly elucidated. The aim of this study was to investigate the differentially expressed proteins of intestinal mucosa after intestinal I/R with or without IPo, and to explore the potential mechanisms of intestinal I/R injury and the protective effect of IPo in relation to the differential proteins.
Melatonin and 1400 W Ameliorate both Intestinal and Remote Organ Injury Following Mesenteric Ischemia/ReperfusionAcute intestinal ischemia reperfusion (I/R) injury affects not only the intestines but also remote organs due to pro-inflammatory and tissue injurious factors. Thus, we aimed to investigate the roles of melatonin (a powerful antioxidant) and 1400W (a strong inhibitor of inducible nitric oxide) in a rat intestinal I/R injury model, since oxidative and nitrosative injury are believed to be the major causes.
Significance of Portal Venous VEGF During Liver Regeneration After HepatectomyAlthough some studies have hypothesized portal venous blood is important for liver regeneration, no studies have established organs whose venous effluent flow into the portal vein secrete liver regenerating factors into the portal vein during liver regeneration. The aim of this study was to elucidate up-regulation of vascular endothelial growth factor (VEGF) in the portal vein, and expressions of hepatic regenerating factors in organs whose venous effluent flows into the portal vein during liver regeneration.