The Effect of Diabetes and Poor Left Ventricular Function on Bone Marrow Cell-Induced Myocardial ProtectionThe myocardium of patients with diabetes and poor left ventricular (LV) function cannot be protected by interventions such as ischemic preconditioning (IP). We investigated whether these clinical conditions influence the protection elicited by the paracrine effect of bone marrow cells (BMCs) and whether the cause for loss in protection resides in the BMCs, the myocardium, or both.
Protective Effects of SP600125 on Renal Ischemia-Reperfusion Injury in RatsIschemia/reperfusion injury (IRI) has a negative effect on renal allograft survival. Using a rat model of kidney IRI in this study, we investigated the overall effect of selective c-Jun N-terminal kinase (JNK) inhibitor SP600125 on renal IRI events.
Cholangiocytes of Cirrhotic Rats are More Tolerant to Ischemia than Normal Rats: A Role for Abnormal Hepatic Arteriovenous Communications?To assess whether cholangiocytes of rats with liver cirrhosis are more tolerant to ischemic changes than normal rats, and whether this is due to arteriovenous fistulas.
The Importance of Engraftment in Flap Revascularization: Confirmation by Laser Speckle Perfusion ImagingThe delivery of proangiogenic agents in clinical trials of wound healing has produced equivocal results, the lack of real-time assessment of vascular growth is a major weakness in monitoring the efficacy of therapeutic angiogenesis, and surgical solutions fall short in addressing the deficiency in microvascular blood supply to ischemic wounds. Therefore, elucidation of the mechanisms involved in ischemia-induced blood vessel growth has potential diagnostic and therapeutic implications in wound healing.
Testosterone-Down-Regulated Akt Pathway During Cardiac Ischemia/Reperfusion: A Mechanism Involving BAD, Bcl-2 and FOXO3aLower levels of myocardial Akt activity in males are associated with a higher incidence of heart failure and worsened cardiac function after ischemia/reperfusion (I/R). While Akt activation by estrogen provides cardioprotection in females, no information exists regarding the effect of testosterone on the myocardial Akt pathway following I/R. We hypothesized that following I/R: (1) endogenous testosterone will decrease myocardial Akt activation in male hearts; (2) endogenous testosterone will mediate downstream signals of Akt, including Bad, Bcl-2, and FOXO3a; (3) administration of exogenous testosterone will recapitulate negative effects on the Akt pathway in castrated male hearts.
Remote Perconditioning Reduces Myocardial Injury in Adult Valve Replacement: A Randomized Controlled TrialRemote perconditioning has been proved to reduce myocardial infarction and improve ventricular function in vivo. This study aims to determine the protection of remote perconditioning against cardiac reperfusion injury in patients undergoing valve replacement.
Protection Against Severe Intestinal Ischemia/Reperfusion Injury in Rats by Intravenous ResveratrolRepetitive enteral or intraperitoneal administration of resveratrol at high doses has recently been found to protect the small intestine against acute ischemia/reperfusion (I/R) injury. In the present work, the protective potential of solvent-free continuous intravenous infusions of small amounts of resveratrol was studied in a model of severe intestinal I/R injury.
Phenylephrine Induces Early and Late Cardioprotection Through Mitochondrial Permeability Transition Pore in the Isolated Rat HeartThe aim of this study was to investigate the role of mitochondrial permeability transition pore (mPTP) in cardioprotection afforded by phenylephrine pretreatment in early and late phases.
Mast Cell Degranulation is Essential for Anastomotic Healing in Well Perfused and Poorly Perfused Rat ColonMast cell degranulation is an important step in early wound healing in the skin however the role of the mast cell in anastomotic healing is less clear. The aim of this study was to investigate the importance of mast cell degranulation in anastomotic healing and to assess whether a promoter of mast cell degranulation could increase anastomotic healing in poorly perfused bowel.
Protection by Pyruvate Infusion in a Rat Model of Severe Intestinal Ischemia-Reperfusion InjurySeveral lines of evidence suggest a strong protective potential of pyruvate against ischemia-reperfusion injury. Here, we studied the effect of pyruvate infusion on injury of the small intestine and on systemic parameters in a rat model of severe mesenteric ischemia-reperfusion injury.