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  • Research Article7

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  • Cheung, Michael C2
  • Koniaris, Leonidas G2
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  • Journal of Surgical Research7

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  • outcomes2
  • acute lung injury1
  • AP-11
  • cachexia1
  • colorectal cancer1
  • complications1
  • fasudil1
  • heme oxygenase-11
  • hepatic resection1
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  • Shock/Sepsis/Trauma/Critical Care

    Pretreatment of Rho Kinase Inhibitor Inhibits Systemic Inflammation and Prevents Endotoxin-Induced Acute Lung Injury in Mice

    Journal of Surgical Research
    Vol. 171Issue 2e209–e214Published online: September 5, 2011
    • Ren Yu Ding
    • Dong Mei Zhao
    • Zhi Dan Zhang
    • Ren Xuan Guo
    • Xiao Chun Ma
    Cited in Scopus: 28
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      Systemic inflammatory mediators play an important role in the development of sepsis. In this study, we analyzed the role of Rho kinase in the activation of immune response and acute lung injury in a mouse model of sepsis.
      Pretreatment of Rho Kinase Inhibitor Inhibits Systemic Inflammation and Prevents Endotoxin-Induced Acute Lung Injury in Mice
    • Oncology/Endocrine

      Oncological and Functional Outcomes of Intersphincteric Resection for Low Rectal Cancer

      Journal of Surgical Research
      Vol. 170Issue 1e93–e98Published online: June 6, 2011
      • Li-Jen Kuo
      • Chin-Sheng Hung
      • Chien-Hua Wu
      • Web Wang
      • Ka-Wai Tam
      • Hung-Hua Liang
      • and others
      Cited in Scopus: 40
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        The intersphincteric resection technique has been used to extend the opportunity for sphincter preservation in patients with very low rectal cancer. The aim of this study is to assess the long-term oncological and functional outcomes of intersphincteric resection.
        Oncological and Functional Outcomes of Intersphincteric Resection for Low Rectal Cancer
      • Association for Academic Surgery

        Obesity and Weight Loss at Presentation of Lung Cancer are Associated with Opposite Effects on Survival

        Journal of Surgical Research
        Vol. 170Issue 1e75–e83Published online: May 25, 2011
        • Relin Yang
        • Michael C. Cheung
        • Felipe E. Pedroso
        • Margaret M. Byrne
        • Leonidas G. Koniaris
        • Teresa A. Zimmers
        Cited in Scopus: 76
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          Lung cancer is the second most common neoplasm and the leading cause of cancer deaths in the United States. In cancer, weight loss and obesity are associated with reduced survival. However, the effect of obesity or weight loss at presentation on lung cancer survival has not been well studied.
          Obesity and Weight Loss at Presentation of Lung Cancer are Associated with Opposite Effects on Survival
        • Oncology/Endocrine

          Lack of Survival Benefit Following Adjuvant Radiation in Patients with Retroperitoneal Sarcoma: A SEER Analysis

          Journal of Surgical Research
          Vol. 168Issue 2e173–e180Published online: March 8, 2011
          • Warren H. Tseng
          • Steve R. Martinez
          • Ly Do
          • Robert M. Tamurian
          • Dariusz Borys
          • Robert J. Canter
          Cited in Scopus: 49
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            The benefit of radiation therapy (RT) among patients with retroperitoneal sarcoma (RPS) is controversial. We performed a retrospective analysis of the effect of RT on survival among RPS patients using a nationwide cancer registry.
            Lack of Survival Benefit Following Adjuvant Radiation in Patients with Retroperitoneal Sarcoma: A SEER Analysis1
          • Oncology/Endocrine

            Improved Survival with Lymph Node Sampling in Wilms Tumor

            Journal of Surgical Research
            Vol. 167Issue 2e199–e203Published online: January 18, 2011
            • Ying Zhuge
            • Michael C. Cheung
            • Relin Yang
            • Leonidas G. Koniaris
            • Holly L. Neville
            • Juan E. Sola
            Cited in Scopus: 36
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              We sought to determine the impact of number of lymph nodes examined on survival for Wilms tumor (WT).
            • Oncology/Endocrine

              Heme Oxygenase-1 Promoter Polymorphism is a Predictor of Disease Relapse in Pancreatic Neuroendocrine Tumors

              Journal of Surgical Research
              Vol. 166Issue 2e121–e127Published online: December 20, 2010
              • Yogesh K. Vashist
              • Guentac Uzunoglu
              • Lena Deutsch
              • Viacheslav Kalinin
              • Oliver Zehler
              • Adil Alzadjali
              • and others
              Cited in Scopus: 7
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                Current available preoperative diagnostic workup is insufficient to differentiate between benign and malignant pancreatic neuroendocrine tumors (PNET). The aim of the present study was to evaluate the potential prognostic role of the promoter GTn repeat polymorphism (GTn) of the heme oxygenase-1 gene in PNET.
                Heme Oxygenase-1 Promoter Polymorphism is a Predictor of Disease Relapse in Pancreatic Neuroendocrine Tumors
              • Oncology/Endocrine

                Impact of Complications After Surgery for Colorectal Liver Metastasis on Patient Survival

                Journal of Surgical Research
                Vol. 164Issue 1e91–e97Published online: August 2, 2010
                • Abbey Schepers
                • Sven Mieog
                • Boudewijn Borger van de Burg
                • Jan van Schaik
                • Gerrit-Jan Liefers
                • Perla J. Marang-van de Mheen
                Cited in Scopus: 12
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                  In some patients with colorectal liver metastases it is not clear whether liver resection or isolated liver perfusion is the best treatment option. For instance, the risk of complications after surgery may be so substantial and affect subsequent survival. Aim of the present study is to compare complication occurrence and its effect on survival after liver resection and perfusion.
                  Impact of Complications After Surgery for Colorectal Liver Metastasis on Patient Survival
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